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Lysine methylation of PPP1CA by the methyltransferase SUV39H2 disrupts TFEB-dependent autophagy and promotes intervertebral disc degeneration

Impaired transcription factor EB (TFEB) function and deficient autophagy activity have been shown to aggravate intervertebral disc (IVD) degeneration (IDD), yet the underlying mechanisms remain less clear. Protein posttranslational modifications (PTMs) are critical for determining TFEB trafficking a...

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Detalles Bibliográficos
Autores principales:	Liang, Huaizhen, Luo, Rongjin, Li, Gaocai, Zhang, Weifeng, Zhu, Dingchao, Wu, Di, Zhou, Xingyu, Tong, Bide, Wang, Bingjin, Feng, Xiaobo, Wang, Kun, Song, Yu, Yang, Cao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10482945/ https://www.ncbi.nlm.nih.gov/pubmed/37605006 http://dx.doi.org/10.1038/s41418-023-01210-4

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