A small molecule 20C from Gastrodia elata inhibits α-synuclein aggregation and prevents progression of Parkinson’s disease

Parkinson’s disease (PD) is pathologically manifested by the aggregation of α-synuclein, which has been envisioned as a promising disease-modifying target for PD. Here, we identified 20C, a bibenzyl compound derived from Gastrodia elata, able to inhibit the aggregation of A53T variants of α-synuclei...

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Detalles Bibliográficos
Autores principales: Peng, Ye, Ye, Jun-rui, Wang, Sha-sha, He, Wen-bin, Feng, Zhong-ping, Sun, Hong-shuo, Chu, Shi-feng, Zhang, Zhao, Chen, Nai-hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10482970/
https://www.ncbi.nlm.nih.gov/pubmed/37673867
http://dx.doi.org/10.1038/s41419-023-06116-0

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