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Xanomeline displays concomitant orthosteric and allosteric binding modes at the M(4) mAChR

The M(4) muscarinic acetylcholine receptor (M(4) mAChR) has emerged as a drug target of high therapeutic interest due to its expression in regions of the brain involved in the regulation of psychosis, cognition, and addiction. The mAChR agonist, xanomeline, has provided significant improvement in th...

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Detalles Bibliográficos
Autores principales:	Burger, Wessel A. C., Pham, Vi, Vuckovic, Ziva, Powers, Alexander S., Mobbs, Jesse I., Laloudakis, Yianni, Glukhova, Alisa, Wootten, Denise, Tobin, Andrew B., Sexton, Patrick M., Paul, Steven M., Felder, Christian C., Danev, Radostin, Dror, Ron O., Christopoulos, Arthur, Valant, Celine, Thal, David M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10482975/ https://www.ncbi.nlm.nih.gov/pubmed/37673901 http://dx.doi.org/10.1038/s41467-023-41199-5

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