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Rethinking the detection and diagnosis of Alzheimer’s disease: Outcomes of a European Brain Council project

Alzheimer’s disease (AD), the most common form of dementia, is a progressive and debilitating neurodegenerative condition which robs people of their memory, their independence, their relationships and, ultimately, their lives. It affects close to 7 million people in the European Union (EU) alone. Th...

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Autores principales: Dumas, Annette, Destrebecq, Frédéric, Esposito, Giovanni, Suchonova, Dominika, Steen Frederiksen, Kristian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10483037/
https://www.ncbi.nlm.nih.gov/pubmed/37692977
http://dx.doi.org/10.1016/j.nbas.2023.100093
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author Dumas, Annette
Destrebecq, Frédéric
Esposito, Giovanni
Suchonova, Dominika
Steen Frederiksen, Kristian
author_facet Dumas, Annette
Destrebecq, Frédéric
Esposito, Giovanni
Suchonova, Dominika
Steen Frederiksen, Kristian
author_sort Dumas, Annette
collection PubMed
description Alzheimer’s disease (AD), the most common form of dementia, is a progressive and debilitating neurodegenerative condition which robs people of their memory, their independence, their relationships and, ultimately, their lives. It affects close to 7 million people in the European Union (EU) alone. The detection and diagnosis of AD relies on a system that remains focused on the late stage of the disease, despite a better understanding of the disease progression. Clinical practice and healthcare systems’ readiness to detect, diagnose and treat the disease effectively are still lagging. The use of biomarkers (cerebrospinal fluid tests (CSF) and positron emission tomography scans (PET)), which are central to a diagnostic assessment for people with AD symptoms, as well as relevant diagnostic facilities are under-utilised. PET imaging is expensive and of limited availability, and CSF sampling may be considered invasive. The European Brain Council’s ‘Rethinking Alzheimer’s disease: Detection and diagnosis’ White Paper has looked at the barriers to early diagnosis and how the healthcare systems infrastructure for detection and diagnosis of AD need to be transformed in order for people with AD to benefit from innovative solutions once they become approved for use.
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spelling pubmed-104830372023-09-08 Rethinking the detection and diagnosis of Alzheimer’s disease: Outcomes of a European Brain Council project Dumas, Annette Destrebecq, Frédéric Esposito, Giovanni Suchonova, Dominika Steen Frederiksen, Kristian Aging Brain Article Alzheimer’s disease (AD), the most common form of dementia, is a progressive and debilitating neurodegenerative condition which robs people of their memory, their independence, their relationships and, ultimately, their lives. It affects close to 7 million people in the European Union (EU) alone. The detection and diagnosis of AD relies on a system that remains focused on the late stage of the disease, despite a better understanding of the disease progression. Clinical practice and healthcare systems’ readiness to detect, diagnose and treat the disease effectively are still lagging. The use of biomarkers (cerebrospinal fluid tests (CSF) and positron emission tomography scans (PET)), which are central to a diagnostic assessment for people with AD symptoms, as well as relevant diagnostic facilities are under-utilised. PET imaging is expensive and of limited availability, and CSF sampling may be considered invasive. The European Brain Council’s ‘Rethinking Alzheimer’s disease: Detection and diagnosis’ White Paper has looked at the barriers to early diagnosis and how the healthcare systems infrastructure for detection and diagnosis of AD need to be transformed in order for people with AD to benefit from innovative solutions once they become approved for use. Elsevier 2023-09-02 /pmc/articles/PMC10483037/ /pubmed/37692977 http://dx.doi.org/10.1016/j.nbas.2023.100093 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Dumas, Annette
Destrebecq, Frédéric
Esposito, Giovanni
Suchonova, Dominika
Steen Frederiksen, Kristian
Rethinking the detection and diagnosis of Alzheimer’s disease: Outcomes of a European Brain Council project
title Rethinking the detection and diagnosis of Alzheimer’s disease: Outcomes of a European Brain Council project
title_full Rethinking the detection and diagnosis of Alzheimer’s disease: Outcomes of a European Brain Council project
title_fullStr Rethinking the detection and diagnosis of Alzheimer’s disease: Outcomes of a European Brain Council project
title_full_unstemmed Rethinking the detection and diagnosis of Alzheimer’s disease: Outcomes of a European Brain Council project
title_short Rethinking the detection and diagnosis of Alzheimer’s disease: Outcomes of a European Brain Council project
title_sort rethinking the detection and diagnosis of alzheimer’s disease: outcomes of a european brain council project
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10483037/
https://www.ncbi.nlm.nih.gov/pubmed/37692977
http://dx.doi.org/10.1016/j.nbas.2023.100093
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