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Tobacco Exposure During Pregnancy and Infections in Infants up to 1 Year of Age: The Japan Environment and Children’s Study

BACKGROUND: Tobacco exposure during pregnancy is associated with several adverse outcomes in infants. We investigated the association between tobacco exposure during pregnancy (both active and second-hand) and various infections in infants up to 1 year. METHODS: This prospective cohort study used a...

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Autores principales: Hashimoto, Koichi, Maeda, Hajime, Iwasa, Hajime, Kyozuka, Hyo, Maeda, Ryo, Kume, Yohei, Ono, Takashi, Chishiki, Mina, Sato, Akiko, Ogata, Yuka, Murata, Tsuyoshi, Fujimori, Keiya, Shinoki, Kosei, Nishigori, Hidekazu, Yasumura, Seiji, Hosoya, Mitsuaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japan Epidemiological Association 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10483106/
https://www.ncbi.nlm.nih.gov/pubmed/35400710
http://dx.doi.org/10.2188/jea.JE20210405
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author Hashimoto, Koichi
Maeda, Hajime
Iwasa, Hajime
Kyozuka, Hyo
Maeda, Ryo
Kume, Yohei
Ono, Takashi
Chishiki, Mina
Sato, Akiko
Ogata, Yuka
Murata, Tsuyoshi
Fujimori, Keiya
Shinoki, Kosei
Nishigori, Hidekazu
Yasumura, Seiji
Hosoya, Mitsuaki
author_facet Hashimoto, Koichi
Maeda, Hajime
Iwasa, Hajime
Kyozuka, Hyo
Maeda, Ryo
Kume, Yohei
Ono, Takashi
Chishiki, Mina
Sato, Akiko
Ogata, Yuka
Murata, Tsuyoshi
Fujimori, Keiya
Shinoki, Kosei
Nishigori, Hidekazu
Yasumura, Seiji
Hosoya, Mitsuaki
author_sort Hashimoto, Koichi
collection PubMed
description BACKGROUND: Tobacco exposure during pregnancy is associated with several adverse outcomes in infants. We investigated the association between tobacco exposure during pregnancy (both active and second-hand) and various infections in infants up to 1 year. METHODS: This prospective cohort study used a fixed dataset (jecs-an-20180131) from the Japan Environment and Children’s Study of registered births in Japan during 2011–2014 that included 104,065 fetal records from enrolled pregnant women. Based on the participants’ responses to the questionnaire on smoking status, mothers were first divided into “never smoked,” “quit smoking,” and “current smoker” groups and then into “no second-hand smoking (SHS)” and “SHS” groups. Infectious diseases included central nervous system infection, otitis media (OM), upper respiratory tract infection (URTI), lower respiratory tract infection (LRTI), gastroenteritis (GI), and urinary tract infection. Adjusted odds ratios (aORs) and 95% confidence intervals (CIs) were calculated using logistic regression analysis and adjusted for maternal, socioeconomic, and postnatal confounding factors. RESULTS: Among the 73,205 newborns enrolled, multivariable analysis revealed that the aOR of LRTI and GI was 1.20 (95% CI, 1.07–1.33) and 1.18 (95% CI, 1.04–1.35), respectively, for the “current smoker with/without SHS” group compared with the “never smoked without SHS” group. “Quit smoking without SHS” was not associated with the risk of LRTI. SHS was associated with an increased risk of OM, URTI, LRTI, and GI, especially with LRTI and GI. CONCLUSION: Exposure to tobacco smoke during pregnancy was associated with an increased risk of OM, URTI, LRTI, and GI in infants during their first year of life.
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spelling pubmed-104831062023-10-05 Tobacco Exposure During Pregnancy and Infections in Infants up to 1 Year of Age: The Japan Environment and Children’s Study Hashimoto, Koichi Maeda, Hajime Iwasa, Hajime Kyozuka, Hyo Maeda, Ryo Kume, Yohei Ono, Takashi Chishiki, Mina Sato, Akiko Ogata, Yuka Murata, Tsuyoshi Fujimori, Keiya Shinoki, Kosei Nishigori, Hidekazu Yasumura, Seiji Hosoya, Mitsuaki J Epidemiol Original Article BACKGROUND: Tobacco exposure during pregnancy is associated with several adverse outcomes in infants. We investigated the association between tobacco exposure during pregnancy (both active and second-hand) and various infections in infants up to 1 year. METHODS: This prospective cohort study used a fixed dataset (jecs-an-20180131) from the Japan Environment and Children’s Study of registered births in Japan during 2011–2014 that included 104,065 fetal records from enrolled pregnant women. Based on the participants’ responses to the questionnaire on smoking status, mothers were first divided into “never smoked,” “quit smoking,” and “current smoker” groups and then into “no second-hand smoking (SHS)” and “SHS” groups. Infectious diseases included central nervous system infection, otitis media (OM), upper respiratory tract infection (URTI), lower respiratory tract infection (LRTI), gastroenteritis (GI), and urinary tract infection. Adjusted odds ratios (aORs) and 95% confidence intervals (CIs) were calculated using logistic regression analysis and adjusted for maternal, socioeconomic, and postnatal confounding factors. RESULTS: Among the 73,205 newborns enrolled, multivariable analysis revealed that the aOR of LRTI and GI was 1.20 (95% CI, 1.07–1.33) and 1.18 (95% CI, 1.04–1.35), respectively, for the “current smoker with/without SHS” group compared with the “never smoked without SHS” group. “Quit smoking without SHS” was not associated with the risk of LRTI. SHS was associated with an increased risk of OM, URTI, LRTI, and GI, especially with LRTI and GI. CONCLUSION: Exposure to tobacco smoke during pregnancy was associated with an increased risk of OM, URTI, LRTI, and GI in infants during their first year of life. Japan Epidemiological Association 2023-10-05 /pmc/articles/PMC10483106/ /pubmed/35400710 http://dx.doi.org/10.2188/jea.JE20210405 Text en © 2022 Koichi Hashimoto et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Original Article
Hashimoto, Koichi
Maeda, Hajime
Iwasa, Hajime
Kyozuka, Hyo
Maeda, Ryo
Kume, Yohei
Ono, Takashi
Chishiki, Mina
Sato, Akiko
Ogata, Yuka
Murata, Tsuyoshi
Fujimori, Keiya
Shinoki, Kosei
Nishigori, Hidekazu
Yasumura, Seiji
Hosoya, Mitsuaki
Tobacco Exposure During Pregnancy and Infections in Infants up to 1 Year of Age: The Japan Environment and Children’s Study
title Tobacco Exposure During Pregnancy and Infections in Infants up to 1 Year of Age: The Japan Environment and Children’s Study
title_full Tobacco Exposure During Pregnancy and Infections in Infants up to 1 Year of Age: The Japan Environment and Children’s Study
title_fullStr Tobacco Exposure During Pregnancy and Infections in Infants up to 1 Year of Age: The Japan Environment and Children’s Study
title_full_unstemmed Tobacco Exposure During Pregnancy and Infections in Infants up to 1 Year of Age: The Japan Environment and Children’s Study
title_short Tobacco Exposure During Pregnancy and Infections in Infants up to 1 Year of Age: The Japan Environment and Children’s Study
title_sort tobacco exposure during pregnancy and infections in infants up to 1 year of age: the japan environment and children’s study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10483106/
https://www.ncbi.nlm.nih.gov/pubmed/35400710
http://dx.doi.org/10.2188/jea.JE20210405
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