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Long-term survival of LGR5 expressing supporting cells after severe ototoxic trauma in the adult mouse cochlea

INTRODUCTION: The leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5) is a tissue resident stem cell marker, which it is expressed in supporting cells (SCs) in the organ of Corti in the mammalian inner ear. These LGR5+ SCs can be used as an endogenous source of progenitor cells for re...

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Detalles Bibliográficos
Autores principales: Smith-Cortinez, Natalia, Hendriksen, Ferry G. J., Ramekers, Dyan, Stokroos, Robert J., Versnel, Huib, Straatman, Louise V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10483136/
https://www.ncbi.nlm.nih.gov/pubmed/37692553
http://dx.doi.org/10.3389/fncel.2023.1236894