Simultaneous inhibition of Sirtuin 3 and cholesterol homeostasis targets acute myeloid leukemia stem cells by perturbing fatty acid β-oxidation and inducing lipotoxicity

Outcomes for patients with acute myeloid leukemia (AML) remain poor due to the inability of current therapeutic regimens to fully eradicate disease-initiating leukemia stem cells (LSC). Previous studies have demonstrated that oxidative phosphorylation (OXPHOS) is an essential process that is targeta...

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Detalles Bibliográficos
Autores principales: O’Brien, Cristiana, Ling, Tianyi, Berman, Jacob M., Culp-Hill, Rachel, Reisz, Julie A., Rondeau, Vincent, Jahangiri, Soheil, St-Germain, Jonathan, Macwan, Vinitha, Astori, Audrey, Zeng, Andy, Hong, Jun Young, Li, Meng, Yang, Min, Jana, Sadhan, Gamboni, Fabia, Tsao, Emily, Liu, Weiyi, Dick, John E., Lin, Hening, Melnick, Ari, Tikhonova, Anastasia, Arruda, Andrea, Minden, Mark D., Raught, Brian, D'Alessandro, Angelo, Jones, Courtney L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Fondazione Ferrata Storti 2023
Materias:
Article - Acute Myeloid Leukemia
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10483359/
https://www.ncbi.nlm.nih.gov/pubmed/37021547
http://dx.doi.org/10.3324/haematol.2022.281894

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10483359/
https://www.ncbi.nlm.nih.gov/pubmed/37021547
http://dx.doi.org/10.3324/haematol.2022.281894

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