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Cellular and metabolic characteristics of pre-leukemic hematopoietic progenitors with GATA2 haploinsufficiency

Mono-allelic germline disruptions of the transcription factor GATA2 result in a propensity for developing myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML), affecting more than 85% of carriers. How a partial loss of GATA2 functionality enables leukemic transformation years later is unc...

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Detalles Bibliográficos
Autores principales:	Rein, Avigail, Geron, Ifat, Kugler, Eitan, Fishman, Hila, Gottlieb, Eyal, Abramovich, Ifat, Giladi, Amir, Amit, Ido, Mulet-Lazaro, Roger, Delwel, Ruud, Gröschel, Stefan, Levin-Zaidman, Smadar, Dezorella, Nili, Holdengreber, Vered, Rao, Tata Nageswara, Yacobovich, Joanne, Steinberg-Shemer, Orna, Huang, Qiu-Hua, Tan, Yun, Chen, Sai-Juan, Izraeli, Shai, Birger, Yehudit
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Fondazione Ferrata Storti 2022
Materias:	Article - Acute Myeloid Leukemia
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10483369/ https://www.ncbi.nlm.nih.gov/pubmed/36475518 http://dx.doi.org/10.3324/haematol.2022.279437

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