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Pituitary stalk interruption syndrome on MRI: Case report
KEY CLINICAL MESSAGE: Pituitary stalk interruption syndrome (PSIS) is an antenatal anatomical defect characterized by pituitary insufficiency with symptomatology depending on associated hormonal deficits. Diagnosis is often delayed because many clinical findings. The gold standard for detection is p...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10483495/ https://www.ncbi.nlm.nih.gov/pubmed/37692160 http://dx.doi.org/10.1002/ccr3.7899 |
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author | Yehouenou Tessi, Romeo Thierry Adeyemi, Boris El Msaadi, Sihame El Haddad, Siham Allali, Nazik Chat, Latifa |
author_facet | Yehouenou Tessi, Romeo Thierry Adeyemi, Boris El Msaadi, Sihame El Haddad, Siham Allali, Nazik Chat, Latifa |
author_sort | Yehouenou Tessi, Romeo Thierry |
collection | PubMed |
description | KEY CLINICAL MESSAGE: Pituitary stalk interruption syndrome (PSIS) is an antenatal anatomical defect characterized by pituitary insufficiency with symptomatology depending on associated hormonal deficits. Diagnosis is often delayed because many clinical findings. The gold standard for detection is pituitary MRI showing absence of pituitary stalk, anterior pituitary hypoplasia, and postpituitary ectopy. The treatment remains polyhormonal substitution. ABSTRACT: Pituitary stalk interruption syndrome (PSIS) is an antenatal anatomical defect. It is characterized by pituitary insufficiency with symptomatology depending on associated hormonal deficits. Diagnosis of PSIS is often delayed probably because of various clinical characteristics findings. Pituitary imaging abnormality is a specific indicator of hypopituitarism. The symptomatological triad associates a very thin or interrupted pituitary stalk, an ectopic or absent pituitary gland and hypoplasia of the anterior pituitary gland. The gold standard for detection is pituitary MRI. Some genetic factors are associated with the disease. The treatment remains polyhormonal substitution depending on the associated deficits. We reported the case of a 14‐year‐old child with growth retardation in whom the biological work‐up and pituitary MRI concluded that the diagnosis was PSIS with growth hormone deficiency. The treatment implemented was a recombinant growth hormone treatment. The immediate outcome was marked by a regression of symptoms. |
format | Online Article Text |
id | pubmed-10483495 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-104834952023-09-08 Pituitary stalk interruption syndrome on MRI: Case report Yehouenou Tessi, Romeo Thierry Adeyemi, Boris El Msaadi, Sihame El Haddad, Siham Allali, Nazik Chat, Latifa Clin Case Rep Case Report KEY CLINICAL MESSAGE: Pituitary stalk interruption syndrome (PSIS) is an antenatal anatomical defect characterized by pituitary insufficiency with symptomatology depending on associated hormonal deficits. Diagnosis is often delayed because many clinical findings. The gold standard for detection is pituitary MRI showing absence of pituitary stalk, anterior pituitary hypoplasia, and postpituitary ectopy. The treatment remains polyhormonal substitution. ABSTRACT: Pituitary stalk interruption syndrome (PSIS) is an antenatal anatomical defect. It is characterized by pituitary insufficiency with symptomatology depending on associated hormonal deficits. Diagnosis of PSIS is often delayed probably because of various clinical characteristics findings. Pituitary imaging abnormality is a specific indicator of hypopituitarism. The symptomatological triad associates a very thin or interrupted pituitary stalk, an ectopic or absent pituitary gland and hypoplasia of the anterior pituitary gland. The gold standard for detection is pituitary MRI. Some genetic factors are associated with the disease. The treatment remains polyhormonal substitution depending on the associated deficits. We reported the case of a 14‐year‐old child with growth retardation in whom the biological work‐up and pituitary MRI concluded that the diagnosis was PSIS with growth hormone deficiency. The treatment implemented was a recombinant growth hormone treatment. The immediate outcome was marked by a regression of symptoms. John Wiley and Sons Inc. 2023-09-07 /pmc/articles/PMC10483495/ /pubmed/37692160 http://dx.doi.org/10.1002/ccr3.7899 Text en © 2023 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Case Report Yehouenou Tessi, Romeo Thierry Adeyemi, Boris El Msaadi, Sihame El Haddad, Siham Allali, Nazik Chat, Latifa Pituitary stalk interruption syndrome on MRI: Case report |
title | Pituitary stalk interruption syndrome on MRI: Case report |
title_full | Pituitary stalk interruption syndrome on MRI: Case report |
title_fullStr | Pituitary stalk interruption syndrome on MRI: Case report |
title_full_unstemmed | Pituitary stalk interruption syndrome on MRI: Case report |
title_short | Pituitary stalk interruption syndrome on MRI: Case report |
title_sort | pituitary stalk interruption syndrome on mri: case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10483495/ https://www.ncbi.nlm.nih.gov/pubmed/37692160 http://dx.doi.org/10.1002/ccr3.7899 |
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