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Sexual and drug use risk behaviour trajectories among people treated for recent HCV infection: the REACT study

INTRODUCTION: Exploration of sexual and drug use behaviours following treatment for recent hepatitis C virus (HCV) is limited. This analysis modelled behavioural trajectories following treatment for recent HCV and assessed reinfection. METHODS: Participants treated for recent HCV in an international...

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Autores principales: Carson, Joanne M., Barbieri, Sebastiano, Cunningham, Evan, Mao, Eric, van der Valk, Marc, Rockstroh, Jürgen K., Hellard, Margaret, Kim, Arthur, Bhagani, Sanjay, Feld, Jordan J., Gane, Ed, Thurnheer, Maria C., Bruneau, Julie, Tu, Elise, Dore, Gregory J., Matthews, Gail V., Martinello, Marianne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10483502/
https://www.ncbi.nlm.nih.gov/pubmed/37675828
http://dx.doi.org/10.1002/jia2.26168
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author Carson, Joanne M.
Barbieri, Sebastiano
Cunningham, Evan
Mao, Eric
van der Valk, Marc
Rockstroh, Jürgen K.
Hellard, Margaret
Kim, Arthur
Bhagani, Sanjay
Feld, Jordan J.
Gane, Ed
Thurnheer, Maria C.
Bruneau, Julie
Tu, Elise
Dore, Gregory J.
Matthews, Gail V.
Martinello, Marianne
author_facet Carson, Joanne M.
Barbieri, Sebastiano
Cunningham, Evan
Mao, Eric
van der Valk, Marc
Rockstroh, Jürgen K.
Hellard, Margaret
Kim, Arthur
Bhagani, Sanjay
Feld, Jordan J.
Gane, Ed
Thurnheer, Maria C.
Bruneau, Julie
Tu, Elise
Dore, Gregory J.
Matthews, Gail V.
Martinello, Marianne
author_sort Carson, Joanne M.
collection PubMed
description INTRODUCTION: Exploration of sexual and drug use behaviours following treatment for recent hepatitis C virus (HCV) is limited. This analysis modelled behavioural trajectories following treatment for recent HCV and assessed reinfection. METHODS: Participants treated for recent HCV in an international trial (enrolled 2017–2019) were followed at 3‐monthly intervals for up to 2 years to assess longitudinal behaviours. Population‐averaged changes were assessed using generalized estimating equations. Distinct behavioural trajectories were identified using group‐based trajectory modelling. HCV reinfection incidence was calculated using person‐years (PY) of observation. RESULTS: During the follow‐up of 212 participants (84% gay and bisexual men [GBM]; 69% HIV; 26% current injecting drug use [IDU]), behavioural trajectories for IDU and stimulant use (past month) did not change. However, population‐averaged decreases in the likelihood of daily IDU (adjusted odds ratio [AOR] 0.83; 95% CI 0.72, 0.95) and opioid use (AOR 0.84; 95% CI 0.75, 0.93) were observed. Among GBM, behavioural trajectories for chemsex did not change. Population‐averaged decreases in condomless anal intercourse with casual male partners (CAI‐CMP) (AOR 0.95; 95% CI 0.90, 0.99) and group‐sex (AOR 0.86; 95% CI 0.80, 0.93) were observed, but masked distinct trajectories. While a proportion had a decreased probability of CAI‐CMP (23%) and group‐sex (59%) post‐treatment, a substantial proportion retained a high probability of these behaviours. High HCV reinfection incidence was observed for the sustained high probability IDU (33.0/100 PY; 95% CI 17.7, 61.3) and chemsex (23.3/100 PY; 95% CI 14.5, 37.5) trajectories. CONCLUSIONS: Limited sexual and drug use behavioural change was observed following treatment for recent HCV, supporting access to surveillance and (re)treatment.
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spelling pubmed-104835022023-09-08 Sexual and drug use risk behaviour trajectories among people treated for recent HCV infection: the REACT study Carson, Joanne M. Barbieri, Sebastiano Cunningham, Evan Mao, Eric van der Valk, Marc Rockstroh, Jürgen K. Hellard, Margaret Kim, Arthur Bhagani, Sanjay Feld, Jordan J. Gane, Ed Thurnheer, Maria C. Bruneau, Julie Tu, Elise Dore, Gregory J. Matthews, Gail V. Martinello, Marianne J Int AIDS Soc Research Articles INTRODUCTION: Exploration of sexual and drug use behaviours following treatment for recent hepatitis C virus (HCV) is limited. This analysis modelled behavioural trajectories following treatment for recent HCV and assessed reinfection. METHODS: Participants treated for recent HCV in an international trial (enrolled 2017–2019) were followed at 3‐monthly intervals for up to 2 years to assess longitudinal behaviours. Population‐averaged changes were assessed using generalized estimating equations. Distinct behavioural trajectories were identified using group‐based trajectory modelling. HCV reinfection incidence was calculated using person‐years (PY) of observation. RESULTS: During the follow‐up of 212 participants (84% gay and bisexual men [GBM]; 69% HIV; 26% current injecting drug use [IDU]), behavioural trajectories for IDU and stimulant use (past month) did not change. However, population‐averaged decreases in the likelihood of daily IDU (adjusted odds ratio [AOR] 0.83; 95% CI 0.72, 0.95) and opioid use (AOR 0.84; 95% CI 0.75, 0.93) were observed. Among GBM, behavioural trajectories for chemsex did not change. Population‐averaged decreases in condomless anal intercourse with casual male partners (CAI‐CMP) (AOR 0.95; 95% CI 0.90, 0.99) and group‐sex (AOR 0.86; 95% CI 0.80, 0.93) were observed, but masked distinct trajectories. While a proportion had a decreased probability of CAI‐CMP (23%) and group‐sex (59%) post‐treatment, a substantial proportion retained a high probability of these behaviours. High HCV reinfection incidence was observed for the sustained high probability IDU (33.0/100 PY; 95% CI 17.7, 61.3) and chemsex (23.3/100 PY; 95% CI 14.5, 37.5) trajectories. CONCLUSIONS: Limited sexual and drug use behavioural change was observed following treatment for recent HCV, supporting access to surveillance and (re)treatment. John Wiley and Sons Inc. 2023-09-07 /pmc/articles/PMC10483502/ /pubmed/37675828 http://dx.doi.org/10.1002/jia2.26168 Text en © 2023 The Authors. Journal of the International AIDS Society published by John Wiley & Sons Ltd on behalf of the International AIDS Society. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Carson, Joanne M.
Barbieri, Sebastiano
Cunningham, Evan
Mao, Eric
van der Valk, Marc
Rockstroh, Jürgen K.
Hellard, Margaret
Kim, Arthur
Bhagani, Sanjay
Feld, Jordan J.
Gane, Ed
Thurnheer, Maria C.
Bruneau, Julie
Tu, Elise
Dore, Gregory J.
Matthews, Gail V.
Martinello, Marianne
Sexual and drug use risk behaviour trajectories among people treated for recent HCV infection: the REACT study
title Sexual and drug use risk behaviour trajectories among people treated for recent HCV infection: the REACT study
title_full Sexual and drug use risk behaviour trajectories among people treated for recent HCV infection: the REACT study
title_fullStr Sexual and drug use risk behaviour trajectories among people treated for recent HCV infection: the REACT study
title_full_unstemmed Sexual and drug use risk behaviour trajectories among people treated for recent HCV infection: the REACT study
title_short Sexual and drug use risk behaviour trajectories among people treated for recent HCV infection: the REACT study
title_sort sexual and drug use risk behaviour trajectories among people treated for recent hcv infection: the react study
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10483502/
https://www.ncbi.nlm.nih.gov/pubmed/37675828
http://dx.doi.org/10.1002/jia2.26168
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