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Development of brain-penetrable antibody radioligands for in vivo PET imaging of amyloid-β and tau

INTRODUCTION: Alzheimer’s disease (AD) is characterized by the misfolding and aggregation of two major proteins: amyloid-beta (Aβ) and tau. Antibody-based PET radioligands are desirable due to their high specificity and affinity; however, antibody uptake in the brain is limited by the blood–brain ba...

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Detalles Bibliográficos
Autores principales:	Banka, Vinay, Kelleher, Andrew, Sehlin, Dag, Hultqvist, Greta, Sigurdsson, Einar M., Syvänen, Stina, Ding, Yu-Shin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10483511/ https://www.ncbi.nlm.nih.gov/pubmed/37680310 http://dx.doi.org/10.3389/fnume.2023.1173693

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