Targeting mitochondrial energetics reverses panobinostat‐ and marizomib‐induced resistance in pediatric and adult high‐grade gliomas

In previous studies, we demonstrated that panobinostat, a histone deacetylase inhibitor, and bortezomib, a proteasomal inhibitor, displayed synergistic therapeutic activity against pediatric and adult high‐grade gliomas. Despite the remarkable initial response to this combination, resistance emerged...

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Detalles Bibliográficos
Autores principales: Jane, Esther P., Reslink, Matthew C., Gatesman, Taylor A., Halbert, Matthew E., Miller, Tracy A., Golbourn, Brian J., Casillo, Stephanie M., Mullett, Steven J., Wendell, Stacy G., Obodo, Udochukwu, Mohanakrishnan, Dinesh, Dange, Riya, Michealraj, Antony, Brenner, Charles, Agnihotri, Sameer, Premkumar, Daniel R., Pollack, Ian F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10483615/
https://www.ncbi.nlm.nih.gov/pubmed/37014128
http://dx.doi.org/10.1002/1878-0261.13427

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