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Shift work and risk of incident gastroesophageal reflux disease: the association and mediation

INTRODUCTION: Shift work has become an increasingly common work mode globally. This study aimed to investigate the association between shift work and the risk of incident gastroesophageal reflux disease (GORD), an upward gastrointestinal disorder disease worldwide, and to explore the mediating facto...

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Autores principales: Li, Qian, Li, Fu-Rong, Zhen, Shihan, Liao, Jian, Wu, Keye, Li, Xia, Wei, Bincai, Xiao, Zhiyi, Wu, Qingyao, Wu, Xian-Bo, Liang, Fengchao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10483823/
https://www.ncbi.nlm.nih.gov/pubmed/37693713
http://dx.doi.org/10.3389/fpubh.2023.1192517
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author Li, Qian
Li, Fu-Rong
Zhen, Shihan
Liao, Jian
Wu, Keye
Li, Xia
Wei, Bincai
Xiao, Zhiyi
Wu, Qingyao
Wu, Xian-Bo
Liang, Fengchao
author_facet Li, Qian
Li, Fu-Rong
Zhen, Shihan
Liao, Jian
Wu, Keye
Li, Xia
Wei, Bincai
Xiao, Zhiyi
Wu, Qingyao
Wu, Xian-Bo
Liang, Fengchao
author_sort Li, Qian
collection PubMed
description INTRODUCTION: Shift work has become an increasingly common work mode globally. This study aimed to investigate the association between shift work and the risk of incident gastroesophageal reflux disease (GORD), an upward gastrointestinal disorder disease worldwide, and to explore the mediating factors. METHOD: A total of 262,722 participants from the UK Biobank free of GORD and related gastrointestinal diseases were included to investigate the association and potential mediators between shift work and incident GORD. Multivariate-adjusted Cox models were used to evaluate the association between shift work status and GORD incidence. RESULTS: Compared to non-shift workers, shift workers had a 1.10-fold greater risk of incident GORD [95% confidence intervals (CIs): 1.03, 1.18], after adjusting for a range of potential confounders. However, the excess risk of GORD attenuated to the null after further adjusting for selected mediators. Specifically, the association was mediated by sleep patterns (25.7%), healthy behaviors (16.8%), depressive symptoms (20.2%), chronic conditions (13.3%), and biological factors (17.6%). After adjustment for all the mediators together, the association was attenuated by 71.5%. DISCUSSION: Our findings indicated that long-term shift workers may have a higher risk of incident GORD, yet the excess risk may be explained by poor sleep quality, unhealthy behaviors, depressive symptoms, etc. This has positive implications for protecting the health of shift workers.
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spelling pubmed-104838232023-09-08 Shift work and risk of incident gastroesophageal reflux disease: the association and mediation Li, Qian Li, Fu-Rong Zhen, Shihan Liao, Jian Wu, Keye Li, Xia Wei, Bincai Xiao, Zhiyi Wu, Qingyao Wu, Xian-Bo Liang, Fengchao Front Public Health Public Health INTRODUCTION: Shift work has become an increasingly common work mode globally. This study aimed to investigate the association between shift work and the risk of incident gastroesophageal reflux disease (GORD), an upward gastrointestinal disorder disease worldwide, and to explore the mediating factors. METHOD: A total of 262,722 participants from the UK Biobank free of GORD and related gastrointestinal diseases were included to investigate the association and potential mediators between shift work and incident GORD. Multivariate-adjusted Cox models were used to evaluate the association between shift work status and GORD incidence. RESULTS: Compared to non-shift workers, shift workers had a 1.10-fold greater risk of incident GORD [95% confidence intervals (CIs): 1.03, 1.18], after adjusting for a range of potential confounders. However, the excess risk of GORD attenuated to the null after further adjusting for selected mediators. Specifically, the association was mediated by sleep patterns (25.7%), healthy behaviors (16.8%), depressive symptoms (20.2%), chronic conditions (13.3%), and biological factors (17.6%). After adjustment for all the mediators together, the association was attenuated by 71.5%. DISCUSSION: Our findings indicated that long-term shift workers may have a higher risk of incident GORD, yet the excess risk may be explained by poor sleep quality, unhealthy behaviors, depressive symptoms, etc. This has positive implications for protecting the health of shift workers. Frontiers Media S.A. 2023-08-24 /pmc/articles/PMC10483823/ /pubmed/37693713 http://dx.doi.org/10.3389/fpubh.2023.1192517 Text en Copyright © 2023 Li, Li, Zhen, Liao, Wu, Li, Wei, Xiao, Wu, Wu and Liang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Public Health
Li, Qian
Li, Fu-Rong
Zhen, Shihan
Liao, Jian
Wu, Keye
Li, Xia
Wei, Bincai
Xiao, Zhiyi
Wu, Qingyao
Wu, Xian-Bo
Liang, Fengchao
Shift work and risk of incident gastroesophageal reflux disease: the association and mediation
title Shift work and risk of incident gastroesophageal reflux disease: the association and mediation
title_full Shift work and risk of incident gastroesophageal reflux disease: the association and mediation
title_fullStr Shift work and risk of incident gastroesophageal reflux disease: the association and mediation
title_full_unstemmed Shift work and risk of incident gastroesophageal reflux disease: the association and mediation
title_short Shift work and risk of incident gastroesophageal reflux disease: the association and mediation
title_sort shift work and risk of incident gastroesophageal reflux disease: the association and mediation
topic Public Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10483823/
https://www.ncbi.nlm.nih.gov/pubmed/37693713
http://dx.doi.org/10.3389/fpubh.2023.1192517
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