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Is Mutans Streptococci count a risk predictor of Early Childhood Caries? A systematic review and meta-analysis

BACKGROUND: The review aims to determine the risk predictability of mutans streptococci in the development of carious lesions in children with primary dentition. METHODS: Longitudinal observational studies with at least 6 months follow-up and evaluating mutans streptococci presence in caries-free ch...

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Autores principales: Manchanda, Sheetal, Sardana, Divesh, Peng, Simin, Lo, Edward C. M., Chandwani, Neeta, K. Y. Yiu, Cynthia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10483843/
https://www.ncbi.nlm.nih.gov/pubmed/37679718
http://dx.doi.org/10.1186/s12903-023-03346-8
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author Manchanda, Sheetal
Sardana, Divesh
Peng, Simin
Lo, Edward C. M.
Chandwani, Neeta
K. Y. Yiu, Cynthia
author_facet Manchanda, Sheetal
Sardana, Divesh
Peng, Simin
Lo, Edward C. M.
Chandwani, Neeta
K. Y. Yiu, Cynthia
author_sort Manchanda, Sheetal
collection PubMed
description BACKGROUND: The review aims to determine the risk predictability of mutans streptococci in the development of carious lesions in children with primary dentition. METHODS: Longitudinal observational studies with at least 6 months follow-up and evaluating mutans streptococci presence in caries-free children under 6 years of age for the development of any cavitated or non-cavitated carious lesion. Six databases and grey literature were searched without any restrictions. Risk of bias was evaluated using the New Castle Ottawa scale for longitudinal studies, and the certainty of the evidence was evaluated by Grading of Recommendations Assessment, Development and Evaluation using GRADEpro software. Meta-analysis was performed using a random effect (DerSimonian and Laird, DL) model, and heterogeneity was evaluated using tau-squared, I(2) statistics and prediction interval. Sensitivity analysis was performed to assess the relationship between the mutans streptococci presence at baseline and the caries development, according to the sample and methods used for the microbiological assessment and the length of follow-up of the studies. Publication bias was checked by funnel plot using a random effect (DerSimonian and Laird, DL) model. RESULTS: Twelve studies met the inclusion criteria and were included in the review. Four studies received a maximum of 9 stars, and among the remaining eight studies, six received 8 stars and the rest two studies were assigned 7 stars in the risk of bias scale. After pooling the results quantitatively, odds ratio (OR) was found to be 4.13 (95% CI: 3.33, 5.12), suggesting that children with mutans streptococci had 4 times higher odds of developing caries later (p < 0.001). Four studies were pooled to compare future caries experience among children with and without mutans streptococci at baseline, obtaining standardized mean difference (SMD) of 0.85 (95% CI: 0.33, 1.37), indicating a large effect (p < 0.001). Certainty of evidence was found to be moderate, and no publication bias was reported by the funnel plot criteria of symmetry. CONCLUSIONS: Presence of mutans streptococci in a preschool child is a risk predictor for future caries experience. Early identification of children with increased caries-risk may facilitate in implementation of appropriate preventive strategies. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12903-023-03346-8.
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spelling pubmed-104838432023-09-08 Is Mutans Streptococci count a risk predictor of Early Childhood Caries? A systematic review and meta-analysis Manchanda, Sheetal Sardana, Divesh Peng, Simin Lo, Edward C. M. Chandwani, Neeta K. Y. Yiu, Cynthia BMC Oral Health Research BACKGROUND: The review aims to determine the risk predictability of mutans streptococci in the development of carious lesions in children with primary dentition. METHODS: Longitudinal observational studies with at least 6 months follow-up and evaluating mutans streptococci presence in caries-free children under 6 years of age for the development of any cavitated or non-cavitated carious lesion. Six databases and grey literature were searched without any restrictions. Risk of bias was evaluated using the New Castle Ottawa scale for longitudinal studies, and the certainty of the evidence was evaluated by Grading of Recommendations Assessment, Development and Evaluation using GRADEpro software. Meta-analysis was performed using a random effect (DerSimonian and Laird, DL) model, and heterogeneity was evaluated using tau-squared, I(2) statistics and prediction interval. Sensitivity analysis was performed to assess the relationship between the mutans streptococci presence at baseline and the caries development, according to the sample and methods used for the microbiological assessment and the length of follow-up of the studies. Publication bias was checked by funnel plot using a random effect (DerSimonian and Laird, DL) model. RESULTS: Twelve studies met the inclusion criteria and were included in the review. Four studies received a maximum of 9 stars, and among the remaining eight studies, six received 8 stars and the rest two studies were assigned 7 stars in the risk of bias scale. After pooling the results quantitatively, odds ratio (OR) was found to be 4.13 (95% CI: 3.33, 5.12), suggesting that children with mutans streptococci had 4 times higher odds of developing caries later (p < 0.001). Four studies were pooled to compare future caries experience among children with and without mutans streptococci at baseline, obtaining standardized mean difference (SMD) of 0.85 (95% CI: 0.33, 1.37), indicating a large effect (p < 0.001). Certainty of evidence was found to be moderate, and no publication bias was reported by the funnel plot criteria of symmetry. CONCLUSIONS: Presence of mutans streptococci in a preschool child is a risk predictor for future caries experience. Early identification of children with increased caries-risk may facilitate in implementation of appropriate preventive strategies. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12903-023-03346-8. BioMed Central 2023-09-07 /pmc/articles/PMC10483843/ /pubmed/37679718 http://dx.doi.org/10.1186/s12903-023-03346-8 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Manchanda, Sheetal
Sardana, Divesh
Peng, Simin
Lo, Edward C. M.
Chandwani, Neeta
K. Y. Yiu, Cynthia
Is Mutans Streptococci count a risk predictor of Early Childhood Caries? A systematic review and meta-analysis
title Is Mutans Streptococci count a risk predictor of Early Childhood Caries? A systematic review and meta-analysis
title_full Is Mutans Streptococci count a risk predictor of Early Childhood Caries? A systematic review and meta-analysis
title_fullStr Is Mutans Streptococci count a risk predictor of Early Childhood Caries? A systematic review and meta-analysis
title_full_unstemmed Is Mutans Streptococci count a risk predictor of Early Childhood Caries? A systematic review and meta-analysis
title_short Is Mutans Streptococci count a risk predictor of Early Childhood Caries? A systematic review and meta-analysis
title_sort is mutans streptococci count a risk predictor of early childhood caries? a systematic review and meta-analysis
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10483843/
https://www.ncbi.nlm.nih.gov/pubmed/37679718
http://dx.doi.org/10.1186/s12903-023-03346-8
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