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The causal relationship between autoimmune diseases and osteoporosis: a study based on Mendelian randomization

OBJECTIVE: The relationship between different autoimmune diseases and bone mineral density (BMD) and fractures has been reported in epidemiological studies. This study aimed to explore the causal relationship between autoimmune diseases and BMD, falls, and fractures using Mendelian randomization (MR...

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Autores principales: Wu, Shaofeng, Ye, Zhen, Yan, Yi, Zhan, Xinli, Ren, Liang, Zhou, Chenxing, Chen, Tianyou, Yao, Yuanlin, Zhu, Jichong, Wu, Siling, Ma, Fengzhi, Liu, Lu, Fan, Binguang, Liu, Chong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10484226/
https://www.ncbi.nlm.nih.gov/pubmed/37693362
http://dx.doi.org/10.3389/fendo.2023.1196269
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author Wu, Shaofeng
Ye, Zhen
Yan, Yi
Zhan, Xinli
Ren, Liang
Zhou, Chenxing
Chen, Tianyou
Yao, Yuanlin
Zhu, Jichong
Wu, Siling
Ma, Fengzhi
Liu, Lu
Fan, Binguang
Liu, Chong
author_facet Wu, Shaofeng
Ye, Zhen
Yan, Yi
Zhan, Xinli
Ren, Liang
Zhou, Chenxing
Chen, Tianyou
Yao, Yuanlin
Zhu, Jichong
Wu, Siling
Ma, Fengzhi
Liu, Lu
Fan, Binguang
Liu, Chong
author_sort Wu, Shaofeng
collection PubMed
description OBJECTIVE: The relationship between different autoimmune diseases and bone mineral density (BMD) and fractures has been reported in epidemiological studies. This study aimed to explore the causal relationship between autoimmune diseases and BMD, falls, and fractures using Mendelian randomization (MR). METHODS: The instrumental variables were selected from the aggregated statistical data of these diseases from the largest genome-wide association study in Europe. Specifically, 12 common autoimmune diseases were selected as exposure. Outcome variables included BMD, falls, and fractures. Multiple analysis methods were utilized to comprehensively evaluate the causal relationship between autoimmune diseases and BMD, falls, and fractures. Additionally, sensitivity analyses, including Cochran’s Q test, MR-Egger intercept test, and one analysis, were conducted to verify the result’s reliability. RESULTS: Strong evidence was provided in the results of the negatively association of ulcerative colitis (UC) with forearm BMD. UC also had a negatively association with the total body BMD, while inflammatory bowel disease (IBD) depicted a negatively association with the total body BMD at the age of 45–60 years. Horizontal pleiotropy or heterogeneity was not detected through sensitivity analysis, indicating that the causal estimation was reliable. CONCLUSION: This study shows a negative causal relationship between UC and forearm and total body BMD, and between IBD and total body BMD at the age of 45–60 years. These results should be considered in future research and when public health measures and osteoporosis prevention strategies are formulated.
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spelling pubmed-104842262023-09-08 The causal relationship between autoimmune diseases and osteoporosis: a study based on Mendelian randomization Wu, Shaofeng Ye, Zhen Yan, Yi Zhan, Xinli Ren, Liang Zhou, Chenxing Chen, Tianyou Yao, Yuanlin Zhu, Jichong Wu, Siling Ma, Fengzhi Liu, Lu Fan, Binguang Liu, Chong Front Endocrinol (Lausanne) Endocrinology OBJECTIVE: The relationship between different autoimmune diseases and bone mineral density (BMD) and fractures has been reported in epidemiological studies. This study aimed to explore the causal relationship between autoimmune diseases and BMD, falls, and fractures using Mendelian randomization (MR). METHODS: The instrumental variables were selected from the aggregated statistical data of these diseases from the largest genome-wide association study in Europe. Specifically, 12 common autoimmune diseases were selected as exposure. Outcome variables included BMD, falls, and fractures. Multiple analysis methods were utilized to comprehensively evaluate the causal relationship between autoimmune diseases and BMD, falls, and fractures. Additionally, sensitivity analyses, including Cochran’s Q test, MR-Egger intercept test, and one analysis, were conducted to verify the result’s reliability. RESULTS: Strong evidence was provided in the results of the negatively association of ulcerative colitis (UC) with forearm BMD. UC also had a negatively association with the total body BMD, while inflammatory bowel disease (IBD) depicted a negatively association with the total body BMD at the age of 45–60 years. Horizontal pleiotropy or heterogeneity was not detected through sensitivity analysis, indicating that the causal estimation was reliable. CONCLUSION: This study shows a negative causal relationship between UC and forearm and total body BMD, and between IBD and total body BMD at the age of 45–60 years. These results should be considered in future research and when public health measures and osteoporosis prevention strategies are formulated. Frontiers Media S.A. 2023-08-29 /pmc/articles/PMC10484226/ /pubmed/37693362 http://dx.doi.org/10.3389/fendo.2023.1196269 Text en Copyright © 2023 Wu, Ye, Yan, Zhan, Ren, Zhou, Chen, Yao, Zhu, Wu, Ma, Liu, Fan and Liu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Wu, Shaofeng
Ye, Zhen
Yan, Yi
Zhan, Xinli
Ren, Liang
Zhou, Chenxing
Chen, Tianyou
Yao, Yuanlin
Zhu, Jichong
Wu, Siling
Ma, Fengzhi
Liu, Lu
Fan, Binguang
Liu, Chong
The causal relationship between autoimmune diseases and osteoporosis: a study based on Mendelian randomization
title The causal relationship between autoimmune diseases and osteoporosis: a study based on Mendelian randomization
title_full The causal relationship between autoimmune diseases and osteoporosis: a study based on Mendelian randomization
title_fullStr The causal relationship between autoimmune diseases and osteoporosis: a study based on Mendelian randomization
title_full_unstemmed The causal relationship between autoimmune diseases and osteoporosis: a study based on Mendelian randomization
title_short The causal relationship between autoimmune diseases and osteoporosis: a study based on Mendelian randomization
title_sort causal relationship between autoimmune diseases and osteoporosis: a study based on mendelian randomization
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10484226/
https://www.ncbi.nlm.nih.gov/pubmed/37693362
http://dx.doi.org/10.3389/fendo.2023.1196269
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