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The role of the symbiotic microecosystem in cancer: gut microbiota, metabolome, and host immunome
The gut microbiota is not just a simple nutritional symbiosis that parasitizes the host; it is a complex and dynamic ecosystem that coevolves actively with the host and is involved in a variety of biological activities such as circadian rhythm regulation, energy metabolism, and immune response. The...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10484231/ https://www.ncbi.nlm.nih.gov/pubmed/37691931 http://dx.doi.org/10.3389/fimmu.2023.1235827 |
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author | Xue, Xiaoyu Li, Rui Chen, Zhenni Li, Guiyu Liu, Bisheng Guo, Shanshan Yue, Qianhua Yang, Siye Xie, Linlin Zhang, Yiguan Zhao, Junning Tan, Ruirong |
author_facet | Xue, Xiaoyu Li, Rui Chen, Zhenni Li, Guiyu Liu, Bisheng Guo, Shanshan Yue, Qianhua Yang, Siye Xie, Linlin Zhang, Yiguan Zhao, Junning Tan, Ruirong |
author_sort | Xue, Xiaoyu |
collection | PubMed |
description | The gut microbiota is not just a simple nutritional symbiosis that parasitizes the host; it is a complex and dynamic ecosystem that coevolves actively with the host and is involved in a variety of biological activities such as circadian rhythm regulation, energy metabolism, and immune response. The development of the immune system and immunological functions are significantly influenced by the interaction between the host and the microbiota. The interactions between gut microbiota and cancer are of a complex nature. The critical role that the gut microbiota plays in tumor occurrence, progression, and treatment is not clear despite the already done research. The development of precision medicine and cancer immunotherapy further emphasizes the importance and significance of the question of how the microbiota takes part in cancer development, progression, and treatment. This review summarizes recent literature on the relationship between the gut microbiome and cancer immunology. The findings suggest the existence of a “symbiotic microecosystem” formed by gut microbiota, metabolome, and host immunome that is fundamental for the pathogenesis analysis and the development of therapeutic strategies for cancer. |
format | Online Article Text |
id | pubmed-10484231 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-104842312023-09-08 The role of the symbiotic microecosystem in cancer: gut microbiota, metabolome, and host immunome Xue, Xiaoyu Li, Rui Chen, Zhenni Li, Guiyu Liu, Bisheng Guo, Shanshan Yue, Qianhua Yang, Siye Xie, Linlin Zhang, Yiguan Zhao, Junning Tan, Ruirong Front Immunol Immunology The gut microbiota is not just a simple nutritional symbiosis that parasitizes the host; it is a complex and dynamic ecosystem that coevolves actively with the host and is involved in a variety of biological activities such as circadian rhythm regulation, energy metabolism, and immune response. The development of the immune system and immunological functions are significantly influenced by the interaction between the host and the microbiota. The interactions between gut microbiota and cancer are of a complex nature. The critical role that the gut microbiota plays in tumor occurrence, progression, and treatment is not clear despite the already done research. The development of precision medicine and cancer immunotherapy further emphasizes the importance and significance of the question of how the microbiota takes part in cancer development, progression, and treatment. This review summarizes recent literature on the relationship between the gut microbiome and cancer immunology. The findings suggest the existence of a “symbiotic microecosystem” formed by gut microbiota, metabolome, and host immunome that is fundamental for the pathogenesis analysis and the development of therapeutic strategies for cancer. Frontiers Media S.A. 2023-08-24 /pmc/articles/PMC10484231/ /pubmed/37691931 http://dx.doi.org/10.3389/fimmu.2023.1235827 Text en Copyright © 2023 Xue, Li, Chen, Li, Liu, Guo, Yue, Yang, Xie, Zhang, Zhao and Tan https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Xue, Xiaoyu Li, Rui Chen, Zhenni Li, Guiyu Liu, Bisheng Guo, Shanshan Yue, Qianhua Yang, Siye Xie, Linlin Zhang, Yiguan Zhao, Junning Tan, Ruirong The role of the symbiotic microecosystem in cancer: gut microbiota, metabolome, and host immunome |
title | The role of the symbiotic microecosystem in cancer: gut microbiota, metabolome, and host immunome |
title_full | The role of the symbiotic microecosystem in cancer: gut microbiota, metabolome, and host immunome |
title_fullStr | The role of the symbiotic microecosystem in cancer: gut microbiota, metabolome, and host immunome |
title_full_unstemmed | The role of the symbiotic microecosystem in cancer: gut microbiota, metabolome, and host immunome |
title_short | The role of the symbiotic microecosystem in cancer: gut microbiota, metabolome, and host immunome |
title_sort | role of the symbiotic microecosystem in cancer: gut microbiota, metabolome, and host immunome |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10484231/ https://www.ncbi.nlm.nih.gov/pubmed/37691931 http://dx.doi.org/10.3389/fimmu.2023.1235827 |
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