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Prevalence of SARS-CoV-2 Variants and Disease Outcome of COVID-19 Patients in the Amazonas Region of Peru

Peru was severely affected by COVID-19 with a fatality rate that reached up to 6%. In this study, the relationship between SARS-CoV-2 variants and COVID-19 disease outcome in Amazonas, a region of northeastern Peru, was evaluated. The variants were determined by genomic sequencing, and clinical-epid...

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Autores principales: Campos, Christian J., Pajuelo-Reyes, Cecilia, Rojas, Luis M., De La Cruz-Vargas, Jhony A., Tejedo, Juan R., Tapia-Limonchi, Rafael, Tsukayama, Pablo, Chenet, Stella M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Tropical Medicine and Hygiene 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10484257/
https://www.ncbi.nlm.nih.gov/pubmed/37524331
http://dx.doi.org/10.4269/ajtmh.22-0739
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author Campos, Christian J.
Pajuelo-Reyes, Cecilia
Rojas, Luis M.
De La Cruz-Vargas, Jhony A.
Tejedo, Juan R.
Tapia-Limonchi, Rafael
Tsukayama, Pablo
Chenet, Stella M.
author_facet Campos, Christian J.
Pajuelo-Reyes, Cecilia
Rojas, Luis M.
De La Cruz-Vargas, Jhony A.
Tejedo, Juan R.
Tapia-Limonchi, Rafael
Tsukayama, Pablo
Chenet, Stella M.
author_sort Campos, Christian J.
collection PubMed
description Peru was severely affected by COVID-19 with a fatality rate that reached up to 6%. In this study, the relationship between SARS-CoV-2 variants and COVID-19 disease outcome in Amazonas, a region of northeastern Peru, was evaluated. The variants were determined by genomic sequencing, and clinical-epidemiological data were collected from 590 patients between April 2021 and February 2022. There was no association between mortality and hospitalization with any of the variants, but we did find that Omicron is more likely to infect vaccinated and nonvaccinated people. A significant association was also found between unvaccinated patients and hospitalization. Interestingly, in the indigenous population, there were fewer hospitalizations than in the general population. In conclusion, SARS-CoV-2 variants were not associated with the disease outcome in the Amazonas region, and indigenous population were found to be less vulnerable to severe COVID-19 illness.
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spelling pubmed-104842572023-09-08 Prevalence of SARS-CoV-2 Variants and Disease Outcome of COVID-19 Patients in the Amazonas Region of Peru Campos, Christian J. Pajuelo-Reyes, Cecilia Rojas, Luis M. De La Cruz-Vargas, Jhony A. Tejedo, Juan R. Tapia-Limonchi, Rafael Tsukayama, Pablo Chenet, Stella M. Am J Trop Med Hyg Short Report Peru was severely affected by COVID-19 with a fatality rate that reached up to 6%. In this study, the relationship between SARS-CoV-2 variants and COVID-19 disease outcome in Amazonas, a region of northeastern Peru, was evaluated. The variants were determined by genomic sequencing, and clinical-epidemiological data were collected from 590 patients between April 2021 and February 2022. There was no association between mortality and hospitalization with any of the variants, but we did find that Omicron is more likely to infect vaccinated and nonvaccinated people. A significant association was also found between unvaccinated patients and hospitalization. Interestingly, in the indigenous population, there were fewer hospitalizations than in the general population. In conclusion, SARS-CoV-2 variants were not associated with the disease outcome in the Amazonas region, and indigenous population were found to be less vulnerable to severe COVID-19 illness. The American Society of Tropical Medicine and Hygiene 2023-07-31 2023-09 /pmc/articles/PMC10484257/ /pubmed/37524331 http://dx.doi.org/10.4269/ajtmh.22-0739 Text en © The author(s) https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution (CC-BY) License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Short Report
Campos, Christian J.
Pajuelo-Reyes, Cecilia
Rojas, Luis M.
De La Cruz-Vargas, Jhony A.
Tejedo, Juan R.
Tapia-Limonchi, Rafael
Tsukayama, Pablo
Chenet, Stella M.
Prevalence of SARS-CoV-2 Variants and Disease Outcome of COVID-19 Patients in the Amazonas Region of Peru
title Prevalence of SARS-CoV-2 Variants and Disease Outcome of COVID-19 Patients in the Amazonas Region of Peru
title_full Prevalence of SARS-CoV-2 Variants and Disease Outcome of COVID-19 Patients in the Amazonas Region of Peru
title_fullStr Prevalence of SARS-CoV-2 Variants and Disease Outcome of COVID-19 Patients in the Amazonas Region of Peru
title_full_unstemmed Prevalence of SARS-CoV-2 Variants and Disease Outcome of COVID-19 Patients in the Amazonas Region of Peru
title_short Prevalence of SARS-CoV-2 Variants and Disease Outcome of COVID-19 Patients in the Amazonas Region of Peru
title_sort prevalence of sars-cov-2 variants and disease outcome of covid-19 patients in the amazonas region of peru
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10484257/
https://www.ncbi.nlm.nih.gov/pubmed/37524331
http://dx.doi.org/10.4269/ajtmh.22-0739
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