A novel Queuovirinae lineage of Pseudomonas aeruginosa phages encode dPreQ(0) DNA modifications with a single GA motif that provide restriction and CRISPR Cas9 protection in vitro

Deazaguanine DNA modifications are widespread in phages, particularly in those with pathogenic hosts. Pseudomonas phage iggy substitutes ∼16.5% of its genomic 2′-deoxyguanosine (G) with dPreQ(0), and the iggy deazaguanine transglycosylase (DpdA) is unique in having a strict GA target motif, not obse...

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Detalles Bibliográficos
Autores principales: Olsen, Nikoline S, Nielsen, Tue K, Cui, Liang, Dedon, Peter, Neve, Horst, Hansen, Lars H, Kot, Witold
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10484667/
https://www.ncbi.nlm.nih.gov/pubmed/37503841
http://dx.doi.org/10.1093/nar/gkad622

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