DeSUMOylation of chromatin-bound proteins limits the rapid transcriptional reprogramming induced by daunorubicin in acute myeloid leukemias

Genotoxicants have been used for decades as front-line therapies against cancer on the basis of their DNA-damaging actions. However, some of their non-DNA-damaging effects are also instrumental for killing dividing cells. We report here that the anthracycline Daunorubicin (DNR), one of the main drug...

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Detalles Bibliográficos
Autores principales: Boulanger, Mathias, Aqrouq, Mays, Tempé, Denis, Kifagi, Chamseddine, Ristic, Marko, Akl, Dana, Hallal, Rawan, Carusi, Aude, Gabellier, Ludovic, de Toledo, Marion, Sigurdsson, Jon-Otti, Kaoma, Tony, Andrieu-Soler, Charlotte, Forné, Thierry, Soler, Eric, Hicheri, Yosr, Gueret, Elise, Vallar, Laurent, Olsen, Jesper V, Cartron, Guillaume, Piechaczyk, Marc, Bossis, Guillaume
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10484680/
https://www.ncbi.nlm.nih.gov/pubmed/37462077
http://dx.doi.org/10.1093/nar/gkad581

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