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Large-scale expansions of Friedreich's ataxia GAA•TTC repeats in an experimental human system: role of DNA replication and prevention by LNA-DNA oligonucleotides and PNA oligomers

Friedreich's ataxia (FRDA) is caused by expansions of GAA•TTC repeats in the first intron of the human FXN gene that occur during both intergenerational transmissions and in somatic cells. Here we describe an experimental system to analyze large-scale repeat expansions in cultured human cells....

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Detalles Bibliográficos
Autores principales:	Rastokina, Anastasia, Cebrián, Jorge, Mozafari, Negin, Mandel, Nicholas H, Smith, C I Edvard, Lopes, Massimo, Zain, Rula, Mirkin, Sergei M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10484681/ https://www.ncbi.nlm.nih.gov/pubmed/37216608 http://dx.doi.org/10.1093/nar/gkad441

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