Structure–function analysis of an ancient TsaD–TsaC–SUA5–TcdA modular enzyme reveals a prototype of tRNA t(6)A and ct(6)A synthetases

N (6)-threonylcarbamoyladenosine (t(6)A) is a post-transcriptional modification found uniquely at position 37 of tRNAs that decipher ANN-codons in the three domains of life. tRNA t(6)A plays a pivotal role in promoting translational fidelity and maintaining protein homeostasis. The biosynthesis of t...

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Detalles Bibliográficos
Autores principales: Jin, Mengqi, Zhang, Zelin, Yu, Zhijiang, Chen, Wei, Wang, Xiaolei, Lei, Dongsheng, Zhang, Wenhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10484737/
https://www.ncbi.nlm.nih.gov/pubmed/37427786
http://dx.doi.org/10.1093/nar/gkad587

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10484737/
https://www.ncbi.nlm.nih.gov/pubmed/37427786
http://dx.doi.org/10.1093/nar/gkad587

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