Acute Interstitial Nephritis with Glomerular Capillary IgA Deposition Following SARS-CoV-2 mRNA Vaccination

We herein report a case of acute kidney injury (AKI) presenting as acute interstitial nephritis (AIN) after the first dose of the BNT162b2 mRNA vaccine against coronavirus disease 2019 (COVID-19). A 69-year-old man with a history of diabetes and hypertension presented with AKI 4 days after receiving...

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Autores principales: Hishida, Erika, Ono, Yuko, Oe, Kazuho, Imai, Toshimi, Yoshizawa, Hiromichi, Nakaya, Takeo, Kawata, Hirotoshi, Akimoto, Tetsu, Saito, Osamu, Nagata, Daisuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10484757/
https://www.ncbi.nlm.nih.gov/pubmed/37587055
http://dx.doi.org/10.2169/internalmedicine.1631-23
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author Hishida, Erika
Ono, Yuko
Oe, Kazuho
Imai, Toshimi
Yoshizawa, Hiromichi
Nakaya, Takeo
Kawata, Hirotoshi
Akimoto, Tetsu
Saito, Osamu
Nagata, Daisuke
author_facet Hishida, Erika
Ono, Yuko
Oe, Kazuho
Imai, Toshimi
Yoshizawa, Hiromichi
Nakaya, Takeo
Kawata, Hirotoshi
Akimoto, Tetsu
Saito, Osamu
Nagata, Daisuke
author_sort Hishida, Erika
collection PubMed
description We herein report a case of acute kidney injury (AKI) presenting as acute interstitial nephritis (AIN) after the first dose of the BNT162b2 mRNA vaccine against coronavirus disease 2019 (COVID-19). A 69-year-old man with a history of diabetes and hypertension presented with AKI 4 days after receiving the vaccine. Despite the administration of methylprednisolone pulse treatment, his renal function worsened, which prompted us to initiate temporal hemodialysis. His renal function subsequently improved, and a renal biopsy confirmed AIN and glomerular capillary IgA deposition without apparent crescents. The clinical history and histological findings suggest a relationship between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination and AIN as a rare side effect.
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spelling pubmed-104847572023-09-09 Acute Interstitial Nephritis with Glomerular Capillary IgA Deposition Following SARS-CoV-2 mRNA Vaccination Hishida, Erika Ono, Yuko Oe, Kazuho Imai, Toshimi Yoshizawa, Hiromichi Nakaya, Takeo Kawata, Hirotoshi Akimoto, Tetsu Saito, Osamu Nagata, Daisuke Intern Med Case Report We herein report a case of acute kidney injury (AKI) presenting as acute interstitial nephritis (AIN) after the first dose of the BNT162b2 mRNA vaccine against coronavirus disease 2019 (COVID-19). A 69-year-old man with a history of diabetes and hypertension presented with AKI 4 days after receiving the vaccine. Despite the administration of methylprednisolone pulse treatment, his renal function worsened, which prompted us to initiate temporal hemodialysis. His renal function subsequently improved, and a renal biopsy confirmed AIN and glomerular capillary IgA deposition without apparent crescents. The clinical history and histological findings suggest a relationship between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination and AIN as a rare side effect. The Japanese Society of Internal Medicine 2023-08-15 2023-08-15 /pmc/articles/PMC10484757/ /pubmed/37587055 http://dx.doi.org/10.2169/internalmedicine.1631-23 Text en Copyright © 2023 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Hishida, Erika
Ono, Yuko
Oe, Kazuho
Imai, Toshimi
Yoshizawa, Hiromichi
Nakaya, Takeo
Kawata, Hirotoshi
Akimoto, Tetsu
Saito, Osamu
Nagata, Daisuke
Acute Interstitial Nephritis with Glomerular Capillary IgA Deposition Following SARS-CoV-2 mRNA Vaccination
title Acute Interstitial Nephritis with Glomerular Capillary IgA Deposition Following SARS-CoV-2 mRNA Vaccination
title_full Acute Interstitial Nephritis with Glomerular Capillary IgA Deposition Following SARS-CoV-2 mRNA Vaccination
title_fullStr Acute Interstitial Nephritis with Glomerular Capillary IgA Deposition Following SARS-CoV-2 mRNA Vaccination
title_full_unstemmed Acute Interstitial Nephritis with Glomerular Capillary IgA Deposition Following SARS-CoV-2 mRNA Vaccination
title_short Acute Interstitial Nephritis with Glomerular Capillary IgA Deposition Following SARS-CoV-2 mRNA Vaccination
title_sort acute interstitial nephritis with glomerular capillary iga deposition following sars-cov-2 mrna vaccination
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10484757/
https://www.ncbi.nlm.nih.gov/pubmed/37587055
http://dx.doi.org/10.2169/internalmedicine.1631-23
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