Two Elderly Men with Myasthenia Gravis during Androgen Deprivation Therapy for Prostate Cancer

Myasthenia gravis (MG) development is female-dominant in younger patients and male-dominant in older patients. The reason for the sex-ratio inversion in elderly MG patients remains unclear. One possible explanation is the decrease in androgen secretion that occurs with aging, as androgen has an immu...

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Autores principales: Kanazawa, Kazo, Tomizawa, Yuji, Iseki, Tatou, Yokoyama, Kazumasa, Hattori, Nobutaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10484759/
https://www.ncbi.nlm.nih.gov/pubmed/36631089
http://dx.doi.org/10.2169/internalmedicine.0474-22
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author Kanazawa, Kazo
Tomizawa, Yuji
Iseki, Tatou
Yokoyama, Kazumasa
Hattori, Nobutaka
author_facet Kanazawa, Kazo
Tomizawa, Yuji
Iseki, Tatou
Yokoyama, Kazumasa
Hattori, Nobutaka
author_sort Kanazawa, Kazo
collection PubMed
description Myasthenia gravis (MG) development is female-dominant in younger patients and male-dominant in older patients. The reason for the sex-ratio inversion in elderly MG patients remains unclear. One possible explanation is the decrease in androgen secretion that occurs with aging, as androgen has an immunosuppressive function. We experienced two elderly men who developed MG after initiating androgen deprivation therapy (ADT) for treatment of prostate cancer and whose symptoms were ameliorated after ADT cessation. Our cases indicate that MG in older male patients can be caused by an androgen effect.
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spelling pubmed-104847592023-09-09 Two Elderly Men with Myasthenia Gravis during Androgen Deprivation Therapy for Prostate Cancer Kanazawa, Kazo Tomizawa, Yuji Iseki, Tatou Yokoyama, Kazumasa Hattori, Nobutaka Intern Med Case Report Myasthenia gravis (MG) development is female-dominant in younger patients and male-dominant in older patients. The reason for the sex-ratio inversion in elderly MG patients remains unclear. One possible explanation is the decrease in androgen secretion that occurs with aging, as androgen has an immunosuppressive function. We experienced two elderly men who developed MG after initiating androgen deprivation therapy (ADT) for treatment of prostate cancer and whose symptoms were ameliorated after ADT cessation. Our cases indicate that MG in older male patients can be caused by an androgen effect. The Japanese Society of Internal Medicine 2023-01-12 2023-08-15 /pmc/articles/PMC10484759/ /pubmed/36631089 http://dx.doi.org/10.2169/internalmedicine.0474-22 Text en Copyright © 2023 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Kanazawa, Kazo
Tomizawa, Yuji
Iseki, Tatou
Yokoyama, Kazumasa
Hattori, Nobutaka
Two Elderly Men with Myasthenia Gravis during Androgen Deprivation Therapy for Prostate Cancer
title Two Elderly Men with Myasthenia Gravis during Androgen Deprivation Therapy for Prostate Cancer
title_full Two Elderly Men with Myasthenia Gravis during Androgen Deprivation Therapy for Prostate Cancer
title_fullStr Two Elderly Men with Myasthenia Gravis during Androgen Deprivation Therapy for Prostate Cancer
title_full_unstemmed Two Elderly Men with Myasthenia Gravis during Androgen Deprivation Therapy for Prostate Cancer
title_short Two Elderly Men with Myasthenia Gravis during Androgen Deprivation Therapy for Prostate Cancer
title_sort two elderly men with myasthenia gravis during androgen deprivation therapy for prostate cancer
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10484759/
https://www.ncbi.nlm.nih.gov/pubmed/36631089
http://dx.doi.org/10.2169/internalmedicine.0474-22
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