Acute Myocardial Infarction Due to Coronary Artery Embolism during Chemotherapy with mFOLFOX-6 Plus Bevacizumab for Metastatic Colon Cancer

Bevacizumab, a monoclonal antibody against vascular endothelial growth factor, may be associated with arterial embolisms. We herein report a case of acute myocardial infarction caused by coronary embolism during combination chemotherapy with mFOLFOX-6 and bevacizumab in a patient with metastatic col...

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Autores principales: Aoshima, Hiroyuki, Tawarahara, Kei, Kato, Haruta, Ishibashi, Fumimaro, Tokonami, Yuki, Nakamura, Naoki, Matsukura, Gaku, Kanda, Takahiro, Ozeki, Mariko, Ukigai, Hiroshi, Takeuchi, Ryosuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10484765/
https://www.ncbi.nlm.nih.gov/pubmed/36450471
http://dx.doi.org/10.2169/internalmedicine.0788-22
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author Aoshima, Hiroyuki
Tawarahara, Kei
Kato, Haruta
Ishibashi, Fumimaro
Tokonami, Yuki
Nakamura, Naoki
Matsukura, Gaku
Kanda, Takahiro
Ozeki, Mariko
Ukigai, Hiroshi
Takeuchi, Ryosuke
author_facet Aoshima, Hiroyuki
Tawarahara, Kei
Kato, Haruta
Ishibashi, Fumimaro
Tokonami, Yuki
Nakamura, Naoki
Matsukura, Gaku
Kanda, Takahiro
Ozeki, Mariko
Ukigai, Hiroshi
Takeuchi, Ryosuke
author_sort Aoshima, Hiroyuki
collection PubMed
description Bevacizumab, a monoclonal antibody against vascular endothelial growth factor, may be associated with arterial embolisms. We herein report a case of acute myocardial infarction caused by coronary embolism during combination chemotherapy with mFOLFOX-6 and bevacizumab in a patient with metastatic colon cancer. Thromboembolism occurred only in the distal right posterolateral branch without stenotic lesions or plaque rupture in the proximal branch of the right coronary artery. Sole thromboaspiration was successfully performed; the final angiogram demonstrated no stenosis in the right coronary artery. Bevacizumab may be associated with acute coronary syndrome in patients with coronary risk factors, despite no significant coronary narrowing.
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spelling pubmed-104847652023-09-09 Acute Myocardial Infarction Due to Coronary Artery Embolism during Chemotherapy with mFOLFOX-6 Plus Bevacizumab for Metastatic Colon Cancer Aoshima, Hiroyuki Tawarahara, Kei Kato, Haruta Ishibashi, Fumimaro Tokonami, Yuki Nakamura, Naoki Matsukura, Gaku Kanda, Takahiro Ozeki, Mariko Ukigai, Hiroshi Takeuchi, Ryosuke Intern Med Case Report Bevacizumab, a monoclonal antibody against vascular endothelial growth factor, may be associated with arterial embolisms. We herein report a case of acute myocardial infarction caused by coronary embolism during combination chemotherapy with mFOLFOX-6 and bevacizumab in a patient with metastatic colon cancer. Thromboembolism occurred only in the distal right posterolateral branch without stenotic lesions or plaque rupture in the proximal branch of the right coronary artery. Sole thromboaspiration was successfully performed; the final angiogram demonstrated no stenosis in the right coronary artery. Bevacizumab may be associated with acute coronary syndrome in patients with coronary risk factors, despite no significant coronary narrowing. The Japanese Society of Internal Medicine 2022-11-30 2023-08-15 /pmc/articles/PMC10484765/ /pubmed/36450471 http://dx.doi.org/10.2169/internalmedicine.0788-22 Text en Copyright © 2023 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Aoshima, Hiroyuki
Tawarahara, Kei
Kato, Haruta
Ishibashi, Fumimaro
Tokonami, Yuki
Nakamura, Naoki
Matsukura, Gaku
Kanda, Takahiro
Ozeki, Mariko
Ukigai, Hiroshi
Takeuchi, Ryosuke
Acute Myocardial Infarction Due to Coronary Artery Embolism during Chemotherapy with mFOLFOX-6 Plus Bevacizumab for Metastatic Colon Cancer
title Acute Myocardial Infarction Due to Coronary Artery Embolism during Chemotherapy with mFOLFOX-6 Plus Bevacizumab for Metastatic Colon Cancer
title_full Acute Myocardial Infarction Due to Coronary Artery Embolism during Chemotherapy with mFOLFOX-6 Plus Bevacizumab for Metastatic Colon Cancer
title_fullStr Acute Myocardial Infarction Due to Coronary Artery Embolism during Chemotherapy with mFOLFOX-6 Plus Bevacizumab for Metastatic Colon Cancer
title_full_unstemmed Acute Myocardial Infarction Due to Coronary Artery Embolism during Chemotherapy with mFOLFOX-6 Plus Bevacizumab for Metastatic Colon Cancer
title_short Acute Myocardial Infarction Due to Coronary Artery Embolism during Chemotherapy with mFOLFOX-6 Plus Bevacizumab for Metastatic Colon Cancer
title_sort acute myocardial infarction due to coronary artery embolism during chemotherapy with mfolfox-6 plus bevacizumab for metastatic colon cancer
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10484765/
https://www.ncbi.nlm.nih.gov/pubmed/36450471
http://dx.doi.org/10.2169/internalmedicine.0788-22
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