Spinal Cord Infarction in an Adolescent with Protein S Deficiency: A Case Report and Literature Review

Protein S deficiency causes spinal cord infarction in rare cases. We herein report the first case of severe cervicothoracic cord infarction in an adolescent with protein S deficiency. A 16-year-old boy presented with neck pain, four-limb paralysis, and numbness. Magnetic resonance imaging revealed s...

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Detalles Bibliográficos
Autores principales: Kubota, Takafumi, Hosaka, Tatsuhiko, Ando, Daisuke, Ikeda, Kensuke, Izumi, Rumiko, Misu, Tatsuro, Warita, Hitoshi, Aoki, Masashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10484774/
https://www.ncbi.nlm.nih.gov/pubmed/36631088
http://dx.doi.org/10.2169/internalmedicine.0153-22
Descripción
Sumario:Protein S deficiency causes spinal cord infarction in rare cases. We herein report the first case of severe cervicothoracic cord infarction in an adolescent with protein S deficiency. A 16-year-old boy presented with neck pain, four-limb paralysis, and numbness. Magnetic resonance imaging revealed spinal artery infarction in the C4 to Th4 area. Protein S antigen and activity were decreased. The patient was diagnosed with protein S deficiency-associated cervicothoracic cord infarction, which was treated with anticoagulation. Protein S deficiency should be considered as a potential cause of spinal cord infarction in young healthy patients and should be appropriately treated with anticoagulation.

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