Spinal Cord Infarction in an Adolescent with Protein S Deficiency: A Case Report and Literature Review

Protein S deficiency causes spinal cord infarction in rare cases. We herein report the first case of severe cervicothoracic cord infarction in an adolescent with protein S deficiency. A 16-year-old boy presented with neck pain, four-limb paralysis, and numbness. Magnetic resonance imaging revealed s...

Descripción completa

Detalles Bibliográficos
Autores principales: Kubota, Takafumi, Hosaka, Tatsuhiko, Ando, Daisuke, Ikeda, Kensuke, Izumi, Rumiko, Misu, Tatsuro, Warita, Hitoshi, Aoki, Masashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10484774/
https://www.ncbi.nlm.nih.gov/pubmed/36631088
http://dx.doi.org/10.2169/internalmedicine.0153-22
_version_ 1785102656859013120
author Kubota, Takafumi
Hosaka, Tatsuhiko
Ando, Daisuke
Ikeda, Kensuke
Izumi, Rumiko
Misu, Tatsuro
Warita, Hitoshi
Aoki, Masashi
author_facet Kubota, Takafumi
Hosaka, Tatsuhiko
Ando, Daisuke
Ikeda, Kensuke
Izumi, Rumiko
Misu, Tatsuro
Warita, Hitoshi
Aoki, Masashi
author_sort Kubota, Takafumi
collection PubMed
description Protein S deficiency causes spinal cord infarction in rare cases. We herein report the first case of severe cervicothoracic cord infarction in an adolescent with protein S deficiency. A 16-year-old boy presented with neck pain, four-limb paralysis, and numbness. Magnetic resonance imaging revealed spinal artery infarction in the C4 to Th4 area. Protein S antigen and activity were decreased. The patient was diagnosed with protein S deficiency-associated cervicothoracic cord infarction, which was treated with anticoagulation. Protein S deficiency should be considered as a potential cause of spinal cord infarction in young healthy patients and should be appropriately treated with anticoagulation.
format Online
Article
Text
id pubmed-10484774
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher The Japanese Society of Internal Medicine
record_format MEDLINE/PubMed
spelling pubmed-104847742023-09-09 Spinal Cord Infarction in an Adolescent with Protein S Deficiency: A Case Report and Literature Review Kubota, Takafumi Hosaka, Tatsuhiko Ando, Daisuke Ikeda, Kensuke Izumi, Rumiko Misu, Tatsuro Warita, Hitoshi Aoki, Masashi Intern Med Case Report Protein S deficiency causes spinal cord infarction in rare cases. We herein report the first case of severe cervicothoracic cord infarction in an adolescent with protein S deficiency. A 16-year-old boy presented with neck pain, four-limb paralysis, and numbness. Magnetic resonance imaging revealed spinal artery infarction in the C4 to Th4 area. Protein S antigen and activity were decreased. The patient was diagnosed with protein S deficiency-associated cervicothoracic cord infarction, which was treated with anticoagulation. Protein S deficiency should be considered as a potential cause of spinal cord infarction in young healthy patients and should be appropriately treated with anticoagulation. The Japanese Society of Internal Medicine 2023-01-12 2023-08-15 /pmc/articles/PMC10484774/ /pubmed/36631088 http://dx.doi.org/10.2169/internalmedicine.0153-22 Text en Copyright © 2023 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Kubota, Takafumi
Hosaka, Tatsuhiko
Ando, Daisuke
Ikeda, Kensuke
Izumi, Rumiko
Misu, Tatsuro
Warita, Hitoshi
Aoki, Masashi
Spinal Cord Infarction in an Adolescent with Protein S Deficiency: A Case Report and Literature Review
title Spinal Cord Infarction in an Adolescent with Protein S Deficiency: A Case Report and Literature Review
title_full Spinal Cord Infarction in an Adolescent with Protein S Deficiency: A Case Report and Literature Review
title_fullStr Spinal Cord Infarction in an Adolescent with Protein S Deficiency: A Case Report and Literature Review
title_full_unstemmed Spinal Cord Infarction in an Adolescent with Protein S Deficiency: A Case Report and Literature Review
title_short Spinal Cord Infarction in an Adolescent with Protein S Deficiency: A Case Report and Literature Review
title_sort spinal cord infarction in an adolescent with protein s deficiency: a case report and literature review
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10484774/
https://www.ncbi.nlm.nih.gov/pubmed/36631088
http://dx.doi.org/10.2169/internalmedicine.0153-22
work_keys_str_mv AT kubotatakafumi spinalcordinfarctioninanadolescentwithproteinsdeficiencyacasereportandliteraturereview
AT hosakatatsuhiko spinalcordinfarctioninanadolescentwithproteinsdeficiencyacasereportandliteraturereview
AT andodaisuke spinalcordinfarctioninanadolescentwithproteinsdeficiencyacasereportandliteraturereview
AT ikedakensuke spinalcordinfarctioninanadolescentwithproteinsdeficiencyacasereportandliteraturereview
AT izumirumiko spinalcordinfarctioninanadolescentwithproteinsdeficiencyacasereportandliteraturereview
AT misutatsuro spinalcordinfarctioninanadolescentwithproteinsdeficiencyacasereportandliteraturereview
AT waritahitoshi spinalcordinfarctioninanadolescentwithproteinsdeficiencyacasereportandliteraturereview
AT aokimasashi spinalcordinfarctioninanadolescentwithproteinsdeficiencyacasereportandliteraturereview

Ejemplares similares