Lysosomes mediate the mitochondrial UPR via mTORC1-dependent ATF4 phosphorylation

Lysosomes are central platforms for not only the degradation of macromolecules but also the integration of multiple signaling pathways. However, whether and how lysosomes mediate the mitochondrial stress response (MSR) remain largely unknown. Here, we demonstrate that lysosomal acidification via the...

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Detalles Bibliográficos
Autores principales: Li, Terytty Yang, Wang, Qi, Gao, Arwen W., Li, Xiaoxu, Sun, Yu, Mottis, Adrienne, Shong, Minho, Auwerx, Johan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10484937/
https://www.ncbi.nlm.nih.gov/pubmed/37679337
http://dx.doi.org/10.1038/s41421-023-00589-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10484937/
https://www.ncbi.nlm.nih.gov/pubmed/37679337
http://dx.doi.org/10.1038/s41421-023-00589-1

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