Cargando…
Lysosomes mediate the mitochondrial UPR via mTORC1-dependent ATF4 phosphorylation
Lysosomes are central platforms for not only the degradation of macromolecules but also the integration of multiple signaling pathways. However, whether and how lysosomes mediate the mitochondrial stress response (MSR) remain largely unknown. Here, we demonstrate that lysosomal acidification via the...
| Autores principales: | , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer Nature Singapore
2023
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10484937/ https://www.ncbi.nlm.nih.gov/pubmed/37679337 http://dx.doi.org/10.1038/s41421-023-00589-1 |