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Close-to-lesion transbronchial biopsy: a novel technique to improve suitability of specimens for genetic testing in patients with peripheral pulmonary lesions
Bronchoscopy with radial-probe endobronchial ultrasound, a guide sheath, and electromagnetic navigation can improve the diagnostic yield of peripheral lung nodules. However, the suitability of specimens for genetic analysis remains unsatisfactory. We hypothesized that a transbronchial biopsy perform...
Autores principales: | , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10485017/ https://www.ncbi.nlm.nih.gov/pubmed/37679360 http://dx.doi.org/10.1038/s41598-023-41726-w |
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author | Nishii, Yoichi Sakaguchi, Tadashi Esumi, Seiya Esumi, Maki Nakamura, Yuki Suzuki, Yuta Ito, Kentaro Fujiwara, Kentaro Yasui, Hiroki Ito, Atsushi Tarukawa, Tomohito Tsuruga, Tatsuki D’Alessandro-Gabazza, Corina N. Yasuma, Taro Fujimoto, Hajime Asano, Fumihiro Gabazza, Esteban C. Kobayashi, Tetsu Taguchi, Osamu Hataji, Osamu |
author_facet | Nishii, Yoichi Sakaguchi, Tadashi Esumi, Seiya Esumi, Maki Nakamura, Yuki Suzuki, Yuta Ito, Kentaro Fujiwara, Kentaro Yasui, Hiroki Ito, Atsushi Tarukawa, Tomohito Tsuruga, Tatsuki D’Alessandro-Gabazza, Corina N. Yasuma, Taro Fujimoto, Hajime Asano, Fumihiro Gabazza, Esteban C. Kobayashi, Tetsu Taguchi, Osamu Hataji, Osamu |
author_sort | Nishii, Yoichi |
collection | PubMed |
description | Bronchoscopy with radial-probe endobronchial ultrasound, a guide sheath, and electromagnetic navigation can improve the diagnostic yield of peripheral lung nodules. However, the suitability of specimens for genetic analysis remains unsatisfactory. We hypothesized that a transbronchial biopsy performed after closely approaching the bronchoscope tip to the lesion might provide more suitable specimens for genetic analysis. We enrolled 155 patients with peripheral pulmonary lesions who underwent bronchoscopy with a thin or ultrathin bronchoscope. Bronchoscopy was performed using virtual bronchoscopic navigation and radial-probe endobronchial ultrasound with a guide sheath. The bronchoscope tip was placed closer to the lesion during bronchoscopy to collect larger specimens with higher malignant cell content. The patients who underwent a close-to-lesion biopsy had higher rates of overall diagnostic yield, histopathological diagnostic yield, and specimen quality for genetic testing than those who did not. The significant determinants of the specimen’s suitability were the close-to-lesion approach, within-the-lesion image, the use of standard 1.9-mm-forceps, and the number of cancer-cell-positive specimens. The significant predictors of the specimen’s suitability for genetic analysis were close-to-lesion biopsy and the number of malignant cell-positive tissue samples. This study demonstrates that the close-to-lesion transbronchial biopsy significantly improves the suitability of bronchoscopic specimens for genetic analysis. |
format | Online Article Text |
id | pubmed-10485017 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-104850172023-09-09 Close-to-lesion transbronchial biopsy: a novel technique to improve suitability of specimens for genetic testing in patients with peripheral pulmonary lesions Nishii, Yoichi Sakaguchi, Tadashi Esumi, Seiya Esumi, Maki Nakamura, Yuki Suzuki, Yuta Ito, Kentaro Fujiwara, Kentaro Yasui, Hiroki Ito, Atsushi Tarukawa, Tomohito Tsuruga, Tatsuki D’Alessandro-Gabazza, Corina N. Yasuma, Taro Fujimoto, Hajime Asano, Fumihiro Gabazza, Esteban C. Kobayashi, Tetsu Taguchi, Osamu Hataji, Osamu Sci Rep Article Bronchoscopy with radial-probe endobronchial ultrasound, a guide sheath, and electromagnetic navigation can improve the diagnostic yield of peripheral lung nodules. However, the suitability of specimens for genetic analysis remains unsatisfactory. We hypothesized that a transbronchial biopsy performed after closely approaching the bronchoscope tip to the lesion might provide more suitable specimens for genetic analysis. We enrolled 155 patients with peripheral pulmonary lesions who underwent bronchoscopy with a thin or ultrathin bronchoscope. Bronchoscopy was performed using virtual bronchoscopic navigation and radial-probe endobronchial ultrasound with a guide sheath. The bronchoscope tip was placed closer to the lesion during bronchoscopy to collect larger specimens with higher malignant cell content. The patients who underwent a close-to-lesion biopsy had higher rates of overall diagnostic yield, histopathological diagnostic yield, and specimen quality for genetic testing than those who did not. The significant determinants of the specimen’s suitability were the close-to-lesion approach, within-the-lesion image, the use of standard 1.9-mm-forceps, and the number of cancer-cell-positive specimens. The significant predictors of the specimen’s suitability for genetic analysis were close-to-lesion biopsy and the number of malignant cell-positive tissue samples. This study demonstrates that the close-to-lesion transbronchial biopsy significantly improves the suitability of bronchoscopic specimens for genetic analysis. Nature Publishing Group UK 2023-09-07 /pmc/articles/PMC10485017/ /pubmed/37679360 http://dx.doi.org/10.1038/s41598-023-41726-w Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Nishii, Yoichi Sakaguchi, Tadashi Esumi, Seiya Esumi, Maki Nakamura, Yuki Suzuki, Yuta Ito, Kentaro Fujiwara, Kentaro Yasui, Hiroki Ito, Atsushi Tarukawa, Tomohito Tsuruga, Tatsuki D’Alessandro-Gabazza, Corina N. Yasuma, Taro Fujimoto, Hajime Asano, Fumihiro Gabazza, Esteban C. Kobayashi, Tetsu Taguchi, Osamu Hataji, Osamu Close-to-lesion transbronchial biopsy: a novel technique to improve suitability of specimens for genetic testing in patients with peripheral pulmonary lesions |
title | Close-to-lesion transbronchial biopsy: a novel technique to improve suitability of specimens for genetic testing in patients with peripheral pulmonary lesions |
title_full | Close-to-lesion transbronchial biopsy: a novel technique to improve suitability of specimens for genetic testing in patients with peripheral pulmonary lesions |
title_fullStr | Close-to-lesion transbronchial biopsy: a novel technique to improve suitability of specimens for genetic testing in patients with peripheral pulmonary lesions |
title_full_unstemmed | Close-to-lesion transbronchial biopsy: a novel technique to improve suitability of specimens for genetic testing in patients with peripheral pulmonary lesions |
title_short | Close-to-lesion transbronchial biopsy: a novel technique to improve suitability of specimens for genetic testing in patients with peripheral pulmonary lesions |
title_sort | close-to-lesion transbronchial biopsy: a novel technique to improve suitability of specimens for genetic testing in patients with peripheral pulmonary lesions |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10485017/ https://www.ncbi.nlm.nih.gov/pubmed/37679360 http://dx.doi.org/10.1038/s41598-023-41726-w |
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