Multifaceted membrane interactions of human Atg3 promote LC3-phosphatidylethanolamine conjugation during autophagy

Autophagosome formation, a crucial step in macroautophagy (autophagy), requires the covalent conjugation of LC3 proteins to the amino headgroup of phosphatidylethanolamine (PE) lipids. Atg3, an E2-like enzyme, catalyzes the transfer of LC3 from LC3-Atg3 to PEs in targeted membranes. Here we show tha...

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Detalles Bibliográficos
Autores principales: Ye, Yansheng, Tyndall, Erin R., Bui, Van, Bewley, Maria C., Wang, Guifang, Hong, Xupeng, Shen, Yang, Flanagan, John M., Wang, Hong-Gang, Tian, Fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10485044/
https://www.ncbi.nlm.nih.gov/pubmed/37679347
http://dx.doi.org/10.1038/s41467-023-41243-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10485044/
https://www.ncbi.nlm.nih.gov/pubmed/37679347
http://dx.doi.org/10.1038/s41467-023-41243-4

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