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Visuomotor Adaptation Deficits in Patients with Essential Tremor

Essential tremor (ET) is a progressive movement disorder whose pathophysiology is not fully understood. Current evidence supports the view that the cerebellum is critically involved in the genesis of the tremor in ET. However, it is still unknown whether cerebellar dysfunction affects not only the c...

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Autores principales: Bindel, Laura, Mühlberg, Christoph, Pfeiffer, Victoria, Nitschke, Matthias, Müller, Annekatrin, Wegscheider, Mirko, Rumpf, Jost-Julian, Zeuner, Kirsten E., Becktepe, Jos S., Welzel, Julius, Güthe, Miriam, Classen, Joseph, Tzvi, Elinor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10485096/
https://www.ncbi.nlm.nih.gov/pubmed/36085397
http://dx.doi.org/10.1007/s12311-022-01474-5
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author Bindel, Laura
Mühlberg, Christoph
Pfeiffer, Victoria
Nitschke, Matthias
Müller, Annekatrin
Wegscheider, Mirko
Rumpf, Jost-Julian
Zeuner, Kirsten E.
Becktepe, Jos S.
Welzel, Julius
Güthe, Miriam
Classen, Joseph
Tzvi, Elinor
author_facet Bindel, Laura
Mühlberg, Christoph
Pfeiffer, Victoria
Nitschke, Matthias
Müller, Annekatrin
Wegscheider, Mirko
Rumpf, Jost-Julian
Zeuner, Kirsten E.
Becktepe, Jos S.
Welzel, Julius
Güthe, Miriam
Classen, Joseph
Tzvi, Elinor
author_sort Bindel, Laura
collection PubMed
description Essential tremor (ET) is a progressive movement disorder whose pathophysiology is not fully understood. Current evidence supports the view that the cerebellum is critically involved in the genesis of the tremor in ET. However, it is still unknown whether cerebellar dysfunction affects not only the control of current movements but also the prediction of future movements through dynamic adaptation toward a changed environment. Here, we tested the capacity of 28 patients with ET to adapt in a visuomotor adaptation task known to depend on intact cerebellar function. We found specific impairments in that task compared to age-matched healthy controls. Adaptation to the visual perturbation was disrupted in ET patients, while de-adaptation, the phase after abrupt removal of the perturbation, developed similarly to control subjects. Baseline tremor-independent motor performance was as well similar to healthy controls, indicating that adaptation deficits in ET patients were not rooted in an inability to perform goal-directed movements. There was no association between clinical severity scores of ET and early visuomotor adaptation abilities. These results provide further evidence that the cerebellum is dysfunctional in ET. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s12311-022-01474-5.
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spelling pubmed-104850962023-09-09 Visuomotor Adaptation Deficits in Patients with Essential Tremor Bindel, Laura Mühlberg, Christoph Pfeiffer, Victoria Nitschke, Matthias Müller, Annekatrin Wegscheider, Mirko Rumpf, Jost-Julian Zeuner, Kirsten E. Becktepe, Jos S. Welzel, Julius Güthe, Miriam Classen, Joseph Tzvi, Elinor Cerebellum Original Article Essential tremor (ET) is a progressive movement disorder whose pathophysiology is not fully understood. Current evidence supports the view that the cerebellum is critically involved in the genesis of the tremor in ET. However, it is still unknown whether cerebellar dysfunction affects not only the control of current movements but also the prediction of future movements through dynamic adaptation toward a changed environment. Here, we tested the capacity of 28 patients with ET to adapt in a visuomotor adaptation task known to depend on intact cerebellar function. We found specific impairments in that task compared to age-matched healthy controls. Adaptation to the visual perturbation was disrupted in ET patients, while de-adaptation, the phase after abrupt removal of the perturbation, developed similarly to control subjects. Baseline tremor-independent motor performance was as well similar to healthy controls, indicating that adaptation deficits in ET patients were not rooted in an inability to perform goal-directed movements. There was no association between clinical severity scores of ET and early visuomotor adaptation abilities. These results provide further evidence that the cerebellum is dysfunctional in ET. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s12311-022-01474-5. Springer US 2022-09-09 2023 /pmc/articles/PMC10485096/ /pubmed/36085397 http://dx.doi.org/10.1007/s12311-022-01474-5 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Bindel, Laura
Mühlberg, Christoph
Pfeiffer, Victoria
Nitschke, Matthias
Müller, Annekatrin
Wegscheider, Mirko
Rumpf, Jost-Julian
Zeuner, Kirsten E.
Becktepe, Jos S.
Welzel, Julius
Güthe, Miriam
Classen, Joseph
Tzvi, Elinor
Visuomotor Adaptation Deficits in Patients with Essential Tremor
title Visuomotor Adaptation Deficits in Patients with Essential Tremor
title_full Visuomotor Adaptation Deficits in Patients with Essential Tremor
title_fullStr Visuomotor Adaptation Deficits in Patients with Essential Tremor
title_full_unstemmed Visuomotor Adaptation Deficits in Patients with Essential Tremor
title_short Visuomotor Adaptation Deficits in Patients with Essential Tremor
title_sort visuomotor adaptation deficits in patients with essential tremor
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10485096/
https://www.ncbi.nlm.nih.gov/pubmed/36085397
http://dx.doi.org/10.1007/s12311-022-01474-5
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