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A Study on Urinary Isolates of Candida Species Isolated from Hospitalized Patients with Special Reference to Speciation, Antifungal Susceptibility, and Comparison of Rapid and Conventional Methods of Speciation

AIM: In order to determine which species of Candida were isolated from hospitalized patients’ urine, which risk factors they were linked to, and which antifungal drugs were effective against them, the current investigation was carried out. MATERIALS AND METHODS: One hundred inpatients were part of t...

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Autores principales: Patel, Sanjaykumar P., Nimavat, Keyur, Patel, Pragnesh, Kachhadia, Jenish
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10485411/
https://www.ncbi.nlm.nih.gov/pubmed/37694048
http://dx.doi.org/10.4103/jpbs.jpbs_114_23
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author Patel, Sanjaykumar P.
Nimavat, Keyur
Patel, Pragnesh
Kachhadia, Jenish
author_facet Patel, Sanjaykumar P.
Nimavat, Keyur
Patel, Pragnesh
Kachhadia, Jenish
author_sort Patel, Sanjaykumar P.
collection PubMed
description AIM: In order to determine which species of Candida were isolated from hospitalized patients’ urine, which risk factors they were linked to, and which antifungal drugs were effective against them, the current investigation was carried out. MATERIALS AND METHODS: One hundred inpatients were part of the study group. Urine samples were collected from each subject and spun at 3000 rpm for 10–15 minutes in individual sterile centrifuge tubes. Color, size, texture, and the presence of color diffusion into the surrounding agar were used to identify the distinct Candida species, presumably in 48 hours. RESULTS: A total of 86.7% of the Candida spp. were found to be non-albicans. Major inaccuracies occurred because of differences between methodologies; thus, MBD is the best way to determine antifungal susceptibility to itraconazole and amphotericin B. CONCLUSION: To help clinicians decide on an empirical treatment in an emergency, accurate identification of Candida down to the species level is crucial.
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spelling pubmed-104854112023-09-09 A Study on Urinary Isolates of Candida Species Isolated from Hospitalized Patients with Special Reference to Speciation, Antifungal Susceptibility, and Comparison of Rapid and Conventional Methods of Speciation Patel, Sanjaykumar P. Nimavat, Keyur Patel, Pragnesh Kachhadia, Jenish J Pharm Bioallied Sci Original Article AIM: In order to determine which species of Candida were isolated from hospitalized patients’ urine, which risk factors they were linked to, and which antifungal drugs were effective against them, the current investigation was carried out. MATERIALS AND METHODS: One hundred inpatients were part of the study group. Urine samples were collected from each subject and spun at 3000 rpm for 10–15 minutes in individual sterile centrifuge tubes. Color, size, texture, and the presence of color diffusion into the surrounding agar were used to identify the distinct Candida species, presumably in 48 hours. RESULTS: A total of 86.7% of the Candida spp. were found to be non-albicans. Major inaccuracies occurred because of differences between methodologies; thus, MBD is the best way to determine antifungal susceptibility to itraconazole and amphotericin B. CONCLUSION: To help clinicians decide on an empirical treatment in an emergency, accurate identification of Candida down to the species level is crucial. Wolters Kluwer - Medknow 2023-07 2023-07-11 /pmc/articles/PMC10485411/ /pubmed/37694048 http://dx.doi.org/10.4103/jpbs.jpbs_114_23 Text en Copyright: © 2023 Journal of Pharmacy and Bioallied Sciences https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Patel, Sanjaykumar P.
Nimavat, Keyur
Patel, Pragnesh
Kachhadia, Jenish
A Study on Urinary Isolates of Candida Species Isolated from Hospitalized Patients with Special Reference to Speciation, Antifungal Susceptibility, and Comparison of Rapid and Conventional Methods of Speciation
title A Study on Urinary Isolates of Candida Species Isolated from Hospitalized Patients with Special Reference to Speciation, Antifungal Susceptibility, and Comparison of Rapid and Conventional Methods of Speciation
title_full A Study on Urinary Isolates of Candida Species Isolated from Hospitalized Patients with Special Reference to Speciation, Antifungal Susceptibility, and Comparison of Rapid and Conventional Methods of Speciation
title_fullStr A Study on Urinary Isolates of Candida Species Isolated from Hospitalized Patients with Special Reference to Speciation, Antifungal Susceptibility, and Comparison of Rapid and Conventional Methods of Speciation
title_full_unstemmed A Study on Urinary Isolates of Candida Species Isolated from Hospitalized Patients with Special Reference to Speciation, Antifungal Susceptibility, and Comparison of Rapid and Conventional Methods of Speciation
title_short A Study on Urinary Isolates of Candida Species Isolated from Hospitalized Patients with Special Reference to Speciation, Antifungal Susceptibility, and Comparison of Rapid and Conventional Methods of Speciation
title_sort study on urinary isolates of candida species isolated from hospitalized patients with special reference to speciation, antifungal susceptibility, and comparison of rapid and conventional methods of speciation
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10485411/
https://www.ncbi.nlm.nih.gov/pubmed/37694048
http://dx.doi.org/10.4103/jpbs.jpbs_114_23
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