Cargando…

Choroidal Thickness in Patients with Unilateral Amblyopia and Comparison between Anisometropic and Strabismic Amblyopia: A Prospective Cross-Sectional Study

AIMS AND OBJECTIVES: To determine the choroidal thickness (mainly subfoveal) using spectral domain optical coherence tomography (SD-OCT) in amblyopic eyes and to compare it with the choroidal thickness (CT) of healthy fellow eyes. MATERIALS AND METHODS: In this prospective study, 140 eyes of 70 pati...

Descripción completa

Detalles Bibliográficos
Autores principales: Arora, Priyanka, Goyal, Ashima, Mahapatra, Madhushmita, Arora, Kamaldeep, Verma, Ritesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10485485/
https://www.ncbi.nlm.nih.gov/pubmed/37694002
http://dx.doi.org/10.4103/jpbs.jpbs_132_23
_version_ 1785102797213007872
author Arora, Priyanka
Goyal, Ashima
Mahapatra, Madhushmita
Arora, Kamaldeep
Verma, Ritesh
author_facet Arora, Priyanka
Goyal, Ashima
Mahapatra, Madhushmita
Arora, Kamaldeep
Verma, Ritesh
author_sort Arora, Priyanka
collection PubMed
description AIMS AND OBJECTIVES: To determine the choroidal thickness (mainly subfoveal) using spectral domain optical coherence tomography (SD-OCT) in amblyopic eyes and to compare it with the choroidal thickness (CT) of healthy fellow eyes. MATERIALS AND METHODS: In this prospective study, 140 eyes of 70 patients (aged 5–40 years) with strabismic and anisometropic amblyopia were examined using enhanced depth imaging (EDI) mode in SD-OCT. The CT was measured directly below the fovea and six other locations: 500 μ, 1000 μ, and 1500 μ from fovea in both nasal and temporal quadrants. RESULTS: The mean age of the patients was 22.5 ± 11.2 years. The mean Best Corrected Visual Acuity (BCVA) in the amblyopic eyes was 0.87 ± 0.47 logMAR and 0 ± 0.02 logMAR in control eyes. The average subfoveal CT was 341.73 ± 60.39 μm in the amblyopic eyes and 314.77 ± 48.12 μm in the fellow eyes. Subgroup analysis showed that the patients with anisometropic amblyopia had a significantly thicker choroid as compared to the fellow healthy eyes (P = 0.00), whereas in strabismic amblyopic eyes, this difference was not significantly significant (P = 0.064). CONCLUSION: Significant choroidal thickening was observed in subjects with amblyopia, which may contribute to the amblyopia pathogenesis and this could be used as a diagnostic parameter for amblyopia. These changes were more pronounced in patients with anisometropic amblyopia than strabismic amblyopia.
format Online
Article
Text
id pubmed-10485485
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Wolters Kluwer - Medknow
record_format MEDLINE/PubMed
spelling pubmed-104854852023-09-09 Choroidal Thickness in Patients with Unilateral Amblyopia and Comparison between Anisometropic and Strabismic Amblyopia: A Prospective Cross-Sectional Study Arora, Priyanka Goyal, Ashima Mahapatra, Madhushmita Arora, Kamaldeep Verma, Ritesh J Pharm Bioallied Sci Original Article AIMS AND OBJECTIVES: To determine the choroidal thickness (mainly subfoveal) using spectral domain optical coherence tomography (SD-OCT) in amblyopic eyes and to compare it with the choroidal thickness (CT) of healthy fellow eyes. MATERIALS AND METHODS: In this prospective study, 140 eyes of 70 patients (aged 5–40 years) with strabismic and anisometropic amblyopia were examined using enhanced depth imaging (EDI) mode in SD-OCT. The CT was measured directly below the fovea and six other locations: 500 μ, 1000 μ, and 1500 μ from fovea in both nasal and temporal quadrants. RESULTS: The mean age of the patients was 22.5 ± 11.2 years. The mean Best Corrected Visual Acuity (BCVA) in the amblyopic eyes was 0.87 ± 0.47 logMAR and 0 ± 0.02 logMAR in control eyes. The average subfoveal CT was 341.73 ± 60.39 μm in the amblyopic eyes and 314.77 ± 48.12 μm in the fellow eyes. Subgroup analysis showed that the patients with anisometropic amblyopia had a significantly thicker choroid as compared to the fellow healthy eyes (P = 0.00), whereas in strabismic amblyopic eyes, this difference was not significantly significant (P = 0.064). CONCLUSION: Significant choroidal thickening was observed in subjects with amblyopia, which may contribute to the amblyopia pathogenesis and this could be used as a diagnostic parameter for amblyopia. These changes were more pronounced in patients with anisometropic amblyopia than strabismic amblyopia. Wolters Kluwer - Medknow 2023-07 2023-07-11 /pmc/articles/PMC10485485/ /pubmed/37694002 http://dx.doi.org/10.4103/jpbs.jpbs_132_23 Text en Copyright: © 2023 Journal of Pharmacy and Bioallied Sciences https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Arora, Priyanka
Goyal, Ashima
Mahapatra, Madhushmita
Arora, Kamaldeep
Verma, Ritesh
Choroidal Thickness in Patients with Unilateral Amblyopia and Comparison between Anisometropic and Strabismic Amblyopia: A Prospective Cross-Sectional Study
title Choroidal Thickness in Patients with Unilateral Amblyopia and Comparison between Anisometropic and Strabismic Amblyopia: A Prospective Cross-Sectional Study
title_full Choroidal Thickness in Patients with Unilateral Amblyopia and Comparison between Anisometropic and Strabismic Amblyopia: A Prospective Cross-Sectional Study
title_fullStr Choroidal Thickness in Patients with Unilateral Amblyopia and Comparison between Anisometropic and Strabismic Amblyopia: A Prospective Cross-Sectional Study
title_full_unstemmed Choroidal Thickness in Patients with Unilateral Amblyopia and Comparison between Anisometropic and Strabismic Amblyopia: A Prospective Cross-Sectional Study
title_short Choroidal Thickness in Patients with Unilateral Amblyopia and Comparison between Anisometropic and Strabismic Amblyopia: A Prospective Cross-Sectional Study
title_sort choroidal thickness in patients with unilateral amblyopia and comparison between anisometropic and strabismic amblyopia: a prospective cross-sectional study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10485485/
https://www.ncbi.nlm.nih.gov/pubmed/37694002
http://dx.doi.org/10.4103/jpbs.jpbs_132_23
work_keys_str_mv AT arorapriyanka choroidalthicknessinpatientswithunilateralamblyopiaandcomparisonbetweenanisometropicandstrabismicamblyopiaaprospectivecrosssectionalstudy
AT goyalashima choroidalthicknessinpatientswithunilateralamblyopiaandcomparisonbetweenanisometropicandstrabismicamblyopiaaprospectivecrosssectionalstudy
AT mahapatramadhushmita choroidalthicknessinpatientswithunilateralamblyopiaandcomparisonbetweenanisometropicandstrabismicamblyopiaaprospectivecrosssectionalstudy
AT arorakamaldeep choroidalthicknessinpatientswithunilateralamblyopiaandcomparisonbetweenanisometropicandstrabismicamblyopiaaprospectivecrosssectionalstudy
AT vermaritesh choroidalthicknessinpatientswithunilateralamblyopiaandcomparisonbetweenanisometropicandstrabismicamblyopiaaprospectivecrosssectionalstudy