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The Different MRI Features of Hepatocellular Adenoma and Hepatocellular Carcinoma

BACKGROUND: Hepatocellular adenomas (HCAs) are benign tumours that may be broken down into three different molecular pathogenic categories: catenin activator, hepatic cell nuclear agent 1 (HNF- 1) that has been inactivated, and Inflammatory hepatic adenomas are a genetic and pathological subtype of...

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Autores principales: Abdullah, Ayoob D, Taher, Hayder J., Alareer, Hayder S., Easa, Ahmed M., Dakhil, Hussein A., Bustan, Raad A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10485518/
https://www.ncbi.nlm.nih.gov/pubmed/37693999
http://dx.doi.org/10.4103/jpbs.jpbs_230_23
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author Abdullah, Ayoob D
Taher, Hayder J.
Alareer, Hayder S.
Easa, Ahmed M.
Dakhil, Hussein A.
Bustan, Raad A.
author_facet Abdullah, Ayoob D
Taher, Hayder J.
Alareer, Hayder S.
Easa, Ahmed M.
Dakhil, Hussein A.
Bustan, Raad A.
author_sort Abdullah, Ayoob D
collection PubMed
description BACKGROUND: Hepatocellular adenomas (HCAs) are benign tumours that may be broken down into three different molecular pathogenic categories: catenin activator, hepatic cell nuclear agent 1 (HNF- 1) that has been inactivated, and Inflammatory hepatic adenomas are a genetic and pathological subtype of hepatic adenoma. METHODOLOGY: An analysis of 50 HCA cases was conducted to identify the magnetic resonance imaging characteristics that were specifically related to each HCA subtype IV. This method included 50 patients in total for the study, with 30 of them being new cases. Four cases involving medicine, pathology, surgery, and radiology were gathered and examined. RESULTS: As per these analyses for inactivated HNF-1, the sure predictive esteem about homogeneous indicator spillage on the compound shift pictures could have been as high as 100%, negative predictive quality could have been as high as 94.7%, affectability could have been as high as 86.7%, and specificity could have been as high as 100%. Enhancement of the solid blood vessels to support the ongoing and future stages of the portal vein change. It took a certain predictive quality of 88.5%, a negative predictive worth of about 84%, an affectability of about 85.2%, and more specificity of about 87.5% to diagnose incendiary HCA from the predominant signs seen for T2W successions linked with late constant upgrades. CONCLUSIONS: Both HNF-1–mutated HCAs and incendiary HCAs need to be associated with specific magnetic resonance imaging phenotypes characterized independently as having diffused lipid repartition and sinusoidal expansion.
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spelling pubmed-104855182023-09-09 The Different MRI Features of Hepatocellular Adenoma and Hepatocellular Carcinoma Abdullah, Ayoob D Taher, Hayder J. Alareer, Hayder S. Easa, Ahmed M. Dakhil, Hussein A. Bustan, Raad A. J Pharm Bioallied Sci Original Article BACKGROUND: Hepatocellular adenomas (HCAs) are benign tumours that may be broken down into three different molecular pathogenic categories: catenin activator, hepatic cell nuclear agent 1 (HNF- 1) that has been inactivated, and Inflammatory hepatic adenomas are a genetic and pathological subtype of hepatic adenoma. METHODOLOGY: An analysis of 50 HCA cases was conducted to identify the magnetic resonance imaging characteristics that were specifically related to each HCA subtype IV. This method included 50 patients in total for the study, with 30 of them being new cases. Four cases involving medicine, pathology, surgery, and radiology were gathered and examined. RESULTS: As per these analyses for inactivated HNF-1, the sure predictive esteem about homogeneous indicator spillage on the compound shift pictures could have been as high as 100%, negative predictive quality could have been as high as 94.7%, affectability could have been as high as 86.7%, and specificity could have been as high as 100%. Enhancement of the solid blood vessels to support the ongoing and future stages of the portal vein change. It took a certain predictive quality of 88.5%, a negative predictive worth of about 84%, an affectability of about 85.2%, and more specificity of about 87.5% to diagnose incendiary HCA from the predominant signs seen for T2W successions linked with late constant upgrades. CONCLUSIONS: Both HNF-1–mutated HCAs and incendiary HCAs need to be associated with specific magnetic resonance imaging phenotypes characterized independently as having diffused lipid repartition and sinusoidal expansion. Wolters Kluwer - Medknow 2023-07 2023-07-11 /pmc/articles/PMC10485518/ /pubmed/37693999 http://dx.doi.org/10.4103/jpbs.jpbs_230_23 Text en Copyright: © 2023 Journal of Pharmacy and Bioallied Sciences https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Abdullah, Ayoob D
Taher, Hayder J.
Alareer, Hayder S.
Easa, Ahmed M.
Dakhil, Hussein A.
Bustan, Raad A.
The Different MRI Features of Hepatocellular Adenoma and Hepatocellular Carcinoma
title The Different MRI Features of Hepatocellular Adenoma and Hepatocellular Carcinoma
title_full The Different MRI Features of Hepatocellular Adenoma and Hepatocellular Carcinoma
title_fullStr The Different MRI Features of Hepatocellular Adenoma and Hepatocellular Carcinoma
title_full_unstemmed The Different MRI Features of Hepatocellular Adenoma and Hepatocellular Carcinoma
title_short The Different MRI Features of Hepatocellular Adenoma and Hepatocellular Carcinoma
title_sort different mri features of hepatocellular adenoma and hepatocellular carcinoma
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10485518/
https://www.ncbi.nlm.nih.gov/pubmed/37693999
http://dx.doi.org/10.4103/jpbs.jpbs_230_23
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