Efficacy of Cucurmin and Aloevera Extracts Gel as Local Drugs Delivery Agents

INTRODUCTION: The usage of antimicrobials as local drug delivery (LDD) agents in the treatment of periodontitis has posed limitations due to the development of bacterial resistance, high cost, and unavailability, thus indicating the need for safer and economic alternatives. METHODOLOGY: A split-mouth randomized clinical trial was carried out on 10 patients. Three sites in different quadrants were assigned, treatment modality of scaling and root planing (SRP) alone, SRP with LDD of curcumin gel, and SRP with LDD of 99% pure aloe vera gel, respectively. Clinical parameters were recorded at baseline and on 30(th) day postoperatively. RESULTS: Curcumin and aloe vera in addition to SRP demonstrated improvements in clinical parameters, though 99% aloe vera extract produced more statistically significant results when used as an LDD agent, as shown in intergroup comparisons for changes in periodontal parameters. CONCLUSION: Curcumin 10mg (Curenext) and 99% aloe vera extract as LDD along with regular mechanical debridement is a promising therapy in the treatment of chronic periodontitis.