Lower magnitude and faster waning of antibody responses to SARS-CoV-2 vaccination in anti-TNF-α-treated IBD patients are linked to lack of activation and expansion of cTfh1 cells and impaired B memory cell formation

BACKGROUND: Patients with inflammatory bowel disease (IBD) and healthy controls received primary SARS-CoV-2-mRNA vaccination and a booster after six months. Anti-TNF-α-treated patients showed significantly lower antibody (Ab) levels and faster waning than α4β7-integrin-antagonist recipients and cont...

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Detalles Bibliográficos
Autores principales: Garner-Spitzer, Erika, Wagner, Angelika, Gudipati, Venugopal, Schoetta, Anna-Margarita, Orola-Taus, Maria, Kundi, Michael, Kunert, Renate, Mayrhofer, Patrick, Huppa, Johannes B., Stockinger, Hannes, Carsetti, Rita, Gattinger, Pia, Valenta, Rudolf, Kratzer, Bernhard, Sehgal, Al Nasar Ahmed, Pickl, Winfried F., Reinisch, Walter, Novacek, Gottfried, Wiedermann, Ursula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10485594/
https://www.ncbi.nlm.nih.gov/pubmed/37672867
http://dx.doi.org/10.1016/j.ebiom.2023.104788

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