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Ontogeny, functions and reprogramming of Kupffer cells upon infectious disease

The liver is a vital metabolic organ that also performs important immune-regulatory functions. In the context of infections, the liver represents a target site for various pathogens, while also having an outstanding capacity to filter the blood from pathogens and to contain infections. Pathogen scav...

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Autores principales: Musrati, Mohamed Amer, De Baetselier, Patrick, Movahedi, Kiavash, Van Ginderachter, Jo A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10485603/
https://www.ncbi.nlm.nih.gov/pubmed/37691953
http://dx.doi.org/10.3389/fimmu.2023.1238452
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author Musrati, Mohamed Amer
De Baetselier, Patrick
Movahedi, Kiavash
Van Ginderachter, Jo A.
author_facet Musrati, Mohamed Amer
De Baetselier, Patrick
Movahedi, Kiavash
Van Ginderachter, Jo A.
author_sort Musrati, Mohamed Amer
collection PubMed
description The liver is a vital metabolic organ that also performs important immune-regulatory functions. In the context of infections, the liver represents a target site for various pathogens, while also having an outstanding capacity to filter the blood from pathogens and to contain infections. Pathogen scavenging by the liver is primarily performed by its large and heterogeneous macrophage population. The major liver-resident macrophage population is located within the hepatic microcirculation and is known as Kupffer cells (KCs). Although other minor macrophages reside in the liver as well, KCs remain the best characterized and are the best well-known hepatic macrophage population to be functionally involved in the clearance of infections. The response of KCs to pathogenic insults often governs the overall severity and outcome of infections on the host. Moreover, infections also impart long-lasting, and rarely studied changes to the KC pool. In this review, we discuss current knowledge on the biology and the various roles of liver macrophages during infections. In addition, we reflect on the potential of infection history to imprint long-lasting effects on macrophages, in particular liver macrophages.
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spelling pubmed-104856032023-09-09 Ontogeny, functions and reprogramming of Kupffer cells upon infectious disease Musrati, Mohamed Amer De Baetselier, Patrick Movahedi, Kiavash Van Ginderachter, Jo A. Front Immunol Immunology The liver is a vital metabolic organ that also performs important immune-regulatory functions. In the context of infections, the liver represents a target site for various pathogens, while also having an outstanding capacity to filter the blood from pathogens and to contain infections. Pathogen scavenging by the liver is primarily performed by its large and heterogeneous macrophage population. The major liver-resident macrophage population is located within the hepatic microcirculation and is known as Kupffer cells (KCs). Although other minor macrophages reside in the liver as well, KCs remain the best characterized and are the best well-known hepatic macrophage population to be functionally involved in the clearance of infections. The response of KCs to pathogenic insults often governs the overall severity and outcome of infections on the host. Moreover, infections also impart long-lasting, and rarely studied changes to the KC pool. In this review, we discuss current knowledge on the biology and the various roles of liver macrophages during infections. In addition, we reflect on the potential of infection history to imprint long-lasting effects on macrophages, in particular liver macrophages. Frontiers Media S.A. 2023-08-25 /pmc/articles/PMC10485603/ /pubmed/37691953 http://dx.doi.org/10.3389/fimmu.2023.1238452 Text en Copyright © 2023 Musrati, De Baetselier, Movahedi and Van Ginderachter https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Musrati, Mohamed Amer
De Baetselier, Patrick
Movahedi, Kiavash
Van Ginderachter, Jo A.
Ontogeny, functions and reprogramming of Kupffer cells upon infectious disease
title Ontogeny, functions and reprogramming of Kupffer cells upon infectious disease
title_full Ontogeny, functions and reprogramming of Kupffer cells upon infectious disease
title_fullStr Ontogeny, functions and reprogramming of Kupffer cells upon infectious disease
title_full_unstemmed Ontogeny, functions and reprogramming of Kupffer cells upon infectious disease
title_short Ontogeny, functions and reprogramming of Kupffer cells upon infectious disease
title_sort ontogeny, functions and reprogramming of kupffer cells upon infectious disease
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10485603/
https://www.ncbi.nlm.nih.gov/pubmed/37691953
http://dx.doi.org/10.3389/fimmu.2023.1238452
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