Cargando…

Diagnostic value of the neutrophil lymphocyte ratio in discrimination between tuberculosis and bacterial community acquired pneumonia: A meta-analysis

BACKGROUND: We conducted a systematic review and meta-analysis, based on Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines, to evaluate current literature on diagnostic value of neutrophil to lymphocyte ratio (NLR) in discrimination between tuberculosis (TB) and...

Descripción completa

Detalles Bibliográficos
Autores principales: Shojaan, Horieh, Kalami, Niusha, Ghasempour Alamdari, Masoumeh, Emami Alorizy, Seyed Matin, Ghaedi, Arshin, Bazrgar, Aida, Khanzadeh, Monireh, Lucke-Wold, Brandon, Khanzadeh, Shokoufeh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10485633/
https://www.ncbi.nlm.nih.gov/pubmed/37692090
http://dx.doi.org/10.1016/j.jctube.2023.100395
Descripción
Sumario:BACKGROUND: We conducted a systematic review and meta-analysis, based on Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines, to evaluate current literature on diagnostic value of neutrophil to lymphocyte ratio (NLR) in discrimination between tuberculosis (TB) and bacterial community acquired pneumonia (B-CAP). METHODS: Literature search was conducted from July 20, 2023 using Scopus, PubMed, and Web of Science databases. STATA software (version 12.0; Stata Corporation) was used for all analyses. RESULTS: We found that patients with TB had significantly lower levels of NLR compared to those with B-CAP (SMD = −1.09, 95 %CI = −1.78- −0.40, P = 0.002). In the quality subgroup analysis, we found that patients with TB had significantly lower level of NLR compared to those with B-CAP consistent in moderate (SMD = -0.86, 95 %CI = −2.30, 0.57, P = 0.23) and high-quality studies (SMD = -1.25, 95 %CI = -2.07, −0.42). In the subgroup analysis based on continent, we found that patients with TB had significantly lower level of NLR compared to those with B-CAP in studies performed in Asian populations (SMD = -1.37, 95 %CI = −2.13, −0.61, P < 0.001), but not on African population (SMD = -0.02, 95 %CI = −1.06, 1.02, P = 0.97). The result of this study did not change after execution of sensitivity analysis. The pooled sensitivity of NLR was 0.86 (95% CI = 0.80, 0.91), and the pooled specificity was0.88 (95% CI = 0.69, 0.95). CONCLUSION: Patients with TB had a significantly lower NLR levels compared to those with B-CAP, so we utilized this biomarker for distinguishing between the disorders.