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Quantitative proteomics and phosphoproteomics of PP2A-PPP2R5D variants reveal deregulation of RPS6 phosphorylation via converging signaling cascades

Genetic germline variants of PPP2R5D (encoding: phosphoprotein phosphatase 2 regulatory protein 5D) result in PPP2R5D-related disorder (Jordan’s Syndrome), which is characterized by intellectual disability, hypotonia, seizures, macrocephaly, autism spectrum disorder, and delayed motor skill developm...

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Detalles Bibliográficos
Autores principales:	Smolen, Kali A., Papke, Cinta M., Swingle, Mark R., Musiyenko, Alla, Li, Chenchen, Salter, E. Alan, Camp, Ashley D., Honkanen, Richard E., Kettenbach, Arminja N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10485637/ https://www.ncbi.nlm.nih.gov/pubmed/37572851 http://dx.doi.org/10.1016/j.jbc.2023.105154

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