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Dose decision of HSK7653 oral immediate release tablets in specific populations clinical trials based on mechanistic physiologically-based pharmacokinetic model

HSK7653, an oral dipeptidyl peptidase-4 inhibitor administered every 2 weeks, is a candidate for the treatment of type 2 diabetes mellitus. The major elimination pathway of HSK7653 in vivo is renal excretion, and hepatic metabolism and fecal excretion of unchanged compound contribute less to the sys...

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Detalles Bibliográficos
Autores principales: Zhang, Miao, Zhang, Shudong, Yu, Zhiheng, Yao, Xueting, Lei, Zihan, Yan, Pangke, Wu, Nan, Wang, Xu, Hu, Qin, Liu, Dongyang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science B.V 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10485820/
https://www.ncbi.nlm.nih.gov/pubmed/37532063
http://dx.doi.org/10.1016/j.ejps.2023.106553