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VDR is an essential regulator of hair follicle regression through the progression of cell death

Vitamin D receptor (VDR) is essential for hair follicle homeostasis as its deficiency induces hair loss, although the mechanism involved remains unknown. Our research shows that, in Vdr-knockout mice, the hair cycle is halted during the catagen stage, preceding alopecia. In addition, in Vdr-knockout...

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Autores principales: Joko, Yudai, Yamamoto, Yoko, Kato, Shigeaki, Takemoto, Tatsuya, Abe, Masahiro, Matsumoto, Toshio, Fukumoto, Seiji, Sawatsubashi, Shun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10485823/
https://www.ncbi.nlm.nih.gov/pubmed/37673445
http://dx.doi.org/10.26508/lsa.202302014
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author Joko, Yudai
Yamamoto, Yoko
Kato, Shigeaki
Takemoto, Tatsuya
Abe, Masahiro
Matsumoto, Toshio
Fukumoto, Seiji
Sawatsubashi, Shun
author_facet Joko, Yudai
Yamamoto, Yoko
Kato, Shigeaki
Takemoto, Tatsuya
Abe, Masahiro
Matsumoto, Toshio
Fukumoto, Seiji
Sawatsubashi, Shun
author_sort Joko, Yudai
collection PubMed
description Vitamin D receptor (VDR) is essential for hair follicle homeostasis as its deficiency induces hair loss, although the mechanism involved remains unknown. Our research shows that, in Vdr-knockout mice, the hair cycle is halted during the catagen stage, preceding alopecia. In addition, in Vdr-knockout hair follicles, epithelial strands that normally regress during the catagen phase persist as “surviving epithelial strands.” Single-cell RNA sequencing analysis suggests that these surviving epithelial strands are formed by cells in the lower part of the hair follicle. These findings emphasize the importance of the regression phase in hair follicle regeneration and establish VDR as a regulator of the catagen stage.
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spelling pubmed-104858232023-09-09 VDR is an essential regulator of hair follicle regression through the progression of cell death Joko, Yudai Yamamoto, Yoko Kato, Shigeaki Takemoto, Tatsuya Abe, Masahiro Matsumoto, Toshio Fukumoto, Seiji Sawatsubashi, Shun Life Sci Alliance Research Articles Vitamin D receptor (VDR) is essential for hair follicle homeostasis as its deficiency induces hair loss, although the mechanism involved remains unknown. Our research shows that, in Vdr-knockout mice, the hair cycle is halted during the catagen stage, preceding alopecia. In addition, in Vdr-knockout hair follicles, epithelial strands that normally regress during the catagen phase persist as “surviving epithelial strands.” Single-cell RNA sequencing analysis suggests that these surviving epithelial strands are formed by cells in the lower part of the hair follicle. These findings emphasize the importance of the regression phase in hair follicle regeneration and establish VDR as a regulator of the catagen stage. Life Science Alliance LLC 2023-09-06 /pmc/articles/PMC10485823/ /pubmed/37673445 http://dx.doi.org/10.26508/lsa.202302014 Text en © 2023 Joko et al. https://creativecommons.org/licenses/by/4.0/This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).
spellingShingle Research Articles
Joko, Yudai
Yamamoto, Yoko
Kato, Shigeaki
Takemoto, Tatsuya
Abe, Masahiro
Matsumoto, Toshio
Fukumoto, Seiji
Sawatsubashi, Shun
VDR is an essential regulator of hair follicle regression through the progression of cell death
title VDR is an essential regulator of hair follicle regression through the progression of cell death
title_full VDR is an essential regulator of hair follicle regression through the progression of cell death
title_fullStr VDR is an essential regulator of hair follicle regression through the progression of cell death
title_full_unstemmed VDR is an essential regulator of hair follicle regression through the progression of cell death
title_short VDR is an essential regulator of hair follicle regression through the progression of cell death
title_sort vdr is an essential regulator of hair follicle regression through the progression of cell death
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10485823/
https://www.ncbi.nlm.nih.gov/pubmed/37673445
http://dx.doi.org/10.26508/lsa.202302014
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