Cargando…
VDR is an essential regulator of hair follicle regression through the progression of cell death
Vitamin D receptor (VDR) is essential for hair follicle homeostasis as its deficiency induces hair loss, although the mechanism involved remains unknown. Our research shows that, in Vdr-knockout mice, the hair cycle is halted during the catagen stage, preceding alopecia. In addition, in Vdr-knockout...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Life Science Alliance LLC
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10485823/ https://www.ncbi.nlm.nih.gov/pubmed/37673445 http://dx.doi.org/10.26508/lsa.202302014 |
_version_ | 1785102870659465216 |
---|---|
author | Joko, Yudai Yamamoto, Yoko Kato, Shigeaki Takemoto, Tatsuya Abe, Masahiro Matsumoto, Toshio Fukumoto, Seiji Sawatsubashi, Shun |
author_facet | Joko, Yudai Yamamoto, Yoko Kato, Shigeaki Takemoto, Tatsuya Abe, Masahiro Matsumoto, Toshio Fukumoto, Seiji Sawatsubashi, Shun |
author_sort | Joko, Yudai |
collection | PubMed |
description | Vitamin D receptor (VDR) is essential for hair follicle homeostasis as its deficiency induces hair loss, although the mechanism involved remains unknown. Our research shows that, in Vdr-knockout mice, the hair cycle is halted during the catagen stage, preceding alopecia. In addition, in Vdr-knockout hair follicles, epithelial strands that normally regress during the catagen phase persist as “surviving epithelial strands.” Single-cell RNA sequencing analysis suggests that these surviving epithelial strands are formed by cells in the lower part of the hair follicle. These findings emphasize the importance of the regression phase in hair follicle regeneration and establish VDR as a regulator of the catagen stage. |
format | Online Article Text |
id | pubmed-10485823 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Life Science Alliance LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-104858232023-09-09 VDR is an essential regulator of hair follicle regression through the progression of cell death Joko, Yudai Yamamoto, Yoko Kato, Shigeaki Takemoto, Tatsuya Abe, Masahiro Matsumoto, Toshio Fukumoto, Seiji Sawatsubashi, Shun Life Sci Alliance Research Articles Vitamin D receptor (VDR) is essential for hair follicle homeostasis as its deficiency induces hair loss, although the mechanism involved remains unknown. Our research shows that, in Vdr-knockout mice, the hair cycle is halted during the catagen stage, preceding alopecia. In addition, in Vdr-knockout hair follicles, epithelial strands that normally regress during the catagen phase persist as “surviving epithelial strands.” Single-cell RNA sequencing analysis suggests that these surviving epithelial strands are formed by cells in the lower part of the hair follicle. These findings emphasize the importance of the regression phase in hair follicle regeneration and establish VDR as a regulator of the catagen stage. Life Science Alliance LLC 2023-09-06 /pmc/articles/PMC10485823/ /pubmed/37673445 http://dx.doi.org/10.26508/lsa.202302014 Text en © 2023 Joko et al. https://creativecommons.org/licenses/by/4.0/This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Research Articles Joko, Yudai Yamamoto, Yoko Kato, Shigeaki Takemoto, Tatsuya Abe, Masahiro Matsumoto, Toshio Fukumoto, Seiji Sawatsubashi, Shun VDR is an essential regulator of hair follicle regression through the progression of cell death |
title | VDR is an essential regulator of hair follicle regression through the progression of cell death |
title_full | VDR is an essential regulator of hair follicle regression through the progression of cell death |
title_fullStr | VDR is an essential regulator of hair follicle regression through the progression of cell death |
title_full_unstemmed | VDR is an essential regulator of hair follicle regression through the progression of cell death |
title_short | VDR is an essential regulator of hair follicle regression through the progression of cell death |
title_sort | vdr is an essential regulator of hair follicle regression through the progression of cell death |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10485823/ https://www.ncbi.nlm.nih.gov/pubmed/37673445 http://dx.doi.org/10.26508/lsa.202302014 |
work_keys_str_mv | AT jokoyudai vdrisanessentialregulatorofhairfollicleregressionthroughtheprogressionofcelldeath AT yamamotoyoko vdrisanessentialregulatorofhairfollicleregressionthroughtheprogressionofcelldeath AT katoshigeaki vdrisanessentialregulatorofhairfollicleregressionthroughtheprogressionofcelldeath AT takemototatsuya vdrisanessentialregulatorofhairfollicleregressionthroughtheprogressionofcelldeath AT abemasahiro vdrisanessentialregulatorofhairfollicleregressionthroughtheprogressionofcelldeath AT matsumototoshio vdrisanessentialregulatorofhairfollicleregressionthroughtheprogressionofcelldeath AT fukumotoseiji vdrisanessentialregulatorofhairfollicleregressionthroughtheprogressionofcelldeath AT sawatsubashishun vdrisanessentialregulatorofhairfollicleregressionthroughtheprogressionofcelldeath |