Structure shows that the BIR2 domain of E3 ligase XIAP binds across the RIPK2 kinase dimer interface

RIPK2 is an essential adaptor for NOD signalling and its kinase domain is a drug target for NOD-related diseases, such as inflammatory bowel disease. However, recent work indicates that the phosphorylation activity of RIPK2 is dispensable for signalling and that inhibitors of both RIPK2 activity and...

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Detalles Bibliográficos
Autores principales: Lethier, Mathilde, Huard, Karine, Hons, Michael, Favier, Adrien, Brutscher, Bernhard, Boeri Erba, Elisabetta, Abbott, Derek W, Cusack, Stephen, Pellegrini, Erika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10485824/
https://www.ncbi.nlm.nih.gov/pubmed/37673444
http://dx.doi.org/10.26508/lsa.202201784

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10485824/
https://www.ncbi.nlm.nih.gov/pubmed/37673444
http://dx.doi.org/10.26508/lsa.202201784

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