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Structure shows that the BIR2 domain of E3 ligase XIAP binds across the RIPK2 kinase dimer interface
RIPK2 is an essential adaptor for NOD signalling and its kinase domain is a drug target for NOD-related diseases, such as inflammatory bowel disease. However, recent work indicates that the phosphorylation activity of RIPK2 is dispensable for signalling and that inhibitors of both RIPK2 activity and...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Life Science Alliance LLC
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10485824/ https://www.ncbi.nlm.nih.gov/pubmed/37673444 http://dx.doi.org/10.26508/lsa.202201784 |