Secondary Processes Dominate the Quiescent, Spontaneous Aggregation of α-Synuclein at Physiological pH with Sodium Salts

[Image: see text] The accurate recapitulation in an in vitro assay of the aggregation process of α-synuclein in Parkinson’s disease has been a significant challenge. As α-synuclein does not aggregate spontaneously in most currently used in vitro assays, primary nucleation is triggered by the presenc...

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Detalles Bibliográficos
Autores principales: Horne, Robert I., Metrick, Michael A., Man, Wing, Rinauro, Dillon J., Brotzakis, Z. Faidon, Chia, Sean, Meisl, Georg, Vendruscolo, Michele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10485892/
https://www.ncbi.nlm.nih.gov/pubmed/37578897
http://dx.doi.org/10.1021/acschemneuro.3c00282

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10485892/
https://www.ncbi.nlm.nih.gov/pubmed/37578897
http://dx.doi.org/10.1021/acschemneuro.3c00282

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