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Oxidative Stress Occurs Prior to Amyloid Aβ Plaque Formation and Tau Phosphorylation in Alzheimer’s Disease: Role of Glutathione and Metal Ions
[Image: see text] Alzheimer’s disease (AD) is an insidious and progressive neurodegenerative disorder that affects millions of people worldwide. Although the pathogenesis remains obscure, there are two dominant causal hypotheses. Since last three decades, amyloid beta (Aβ) deposition was the most pr...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10485904/ https://www.ncbi.nlm.nih.gov/pubmed/37561556 http://dx.doi.org/10.1021/acschemneuro.3c00486 |
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author | Roy, Rimil Guha Mandal, Pravat K Maroon, Joseph C. |
author_facet | Roy, Rimil Guha Mandal, Pravat K Maroon, Joseph C. |
author_sort | Roy, Rimil Guha |
collection | PubMed |
description | [Image: see text] Alzheimer’s disease (AD) is an insidious and progressive neurodegenerative disorder that affects millions of people worldwide. Although the pathogenesis remains obscure, there are two dominant causal hypotheses. Since last three decades, amyloid beta (Aβ) deposition was the most prominent hypothesis, and the other is the tau hyperphosphorylation hypothesis. The confirmed diagnostic criterion for AD is the presence of neurofibrillary tangles (NFTs) composed of hyperphosphorylated tau and the deposition of toxic oligomeric Aβ in the autopsied brain. Consistent with these hypotheses, oxidative stress (OS) is garnering major attention in AD research. OS results from an imbalance of pro-oxidants and antioxidants. There is a considerable debate in the scientific community on which process occurs first, OS or plaque deposition/tau hyperphosphorylation. Based on recent scientific observations of various laboratories including ours along with critical analysis of those information, we believe that OS is the early event that leads to oligomeric Aβ deposition as well as dimerization of tau protein and its subsequent hyperphosphorylation. This OS hypothesis immediately suggests the consideration of novel therapeutic approaches to include antioxidants involving glutathione enrichment in the brain by supplementation with or without an iron chelator. |
format | Online Article Text |
id | pubmed-10485904 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-104859042023-09-09 Oxidative Stress Occurs Prior to Amyloid Aβ Plaque Formation and Tau Phosphorylation in Alzheimer’s Disease: Role of Glutathione and Metal Ions Roy, Rimil Guha Mandal, Pravat K Maroon, Joseph C. ACS Chem Neurosci [Image: see text] Alzheimer’s disease (AD) is an insidious and progressive neurodegenerative disorder that affects millions of people worldwide. Although the pathogenesis remains obscure, there are two dominant causal hypotheses. Since last three decades, amyloid beta (Aβ) deposition was the most prominent hypothesis, and the other is the tau hyperphosphorylation hypothesis. The confirmed diagnostic criterion for AD is the presence of neurofibrillary tangles (NFTs) composed of hyperphosphorylated tau and the deposition of toxic oligomeric Aβ in the autopsied brain. Consistent with these hypotheses, oxidative stress (OS) is garnering major attention in AD research. OS results from an imbalance of pro-oxidants and antioxidants. There is a considerable debate in the scientific community on which process occurs first, OS or plaque deposition/tau hyperphosphorylation. Based on recent scientific observations of various laboratories including ours along with critical analysis of those information, we believe that OS is the early event that leads to oligomeric Aβ deposition as well as dimerization of tau protein and its subsequent hyperphosphorylation. This OS hypothesis immediately suggests the consideration of novel therapeutic approaches to include antioxidants involving glutathione enrichment in the brain by supplementation with or without an iron chelator. American Chemical Society 2023-08-10 /pmc/articles/PMC10485904/ /pubmed/37561556 http://dx.doi.org/10.1021/acschemneuro.3c00486 Text en © 2023 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Roy, Rimil Guha Mandal, Pravat K Maroon, Joseph C. Oxidative Stress Occurs Prior to Amyloid Aβ Plaque Formation and Tau Phosphorylation in Alzheimer’s Disease: Role of Glutathione and Metal Ions |
title | Oxidative Stress
Occurs Prior to Amyloid Aβ
Plaque Formation and Tau Phosphorylation in Alzheimer’s Disease:
Role of Glutathione and Metal Ions |
title_full | Oxidative Stress
Occurs Prior to Amyloid Aβ
Plaque Formation and Tau Phosphorylation in Alzheimer’s Disease:
Role of Glutathione and Metal Ions |
title_fullStr | Oxidative Stress
Occurs Prior to Amyloid Aβ
Plaque Formation and Tau Phosphorylation in Alzheimer’s Disease:
Role of Glutathione and Metal Ions |
title_full_unstemmed | Oxidative Stress
Occurs Prior to Amyloid Aβ
Plaque Formation and Tau Phosphorylation in Alzheimer’s Disease:
Role of Glutathione and Metal Ions |
title_short | Oxidative Stress
Occurs Prior to Amyloid Aβ
Plaque Formation and Tau Phosphorylation in Alzheimer’s Disease:
Role of Glutathione and Metal Ions |
title_sort | oxidative stress
occurs prior to amyloid aβ
plaque formation and tau phosphorylation in alzheimer’s disease:
role of glutathione and metal ions |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10485904/ https://www.ncbi.nlm.nih.gov/pubmed/37561556 http://dx.doi.org/10.1021/acschemneuro.3c00486 |
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