Development of a Dihydroquinoline–Pyrazoline GluN2C/2D-Selective Negative Allosteric Modulator of the N-Methyl-d-aspartate Receptor

[Image: see text] Subunit-selective inhibition of N-methyl-d-aspartate receptors (NMDARs) is a promising therapeutic strategy for several neurological disorders, including epilepsy, Alzheimer’s and Parkinson’s disease, depression, and acute brain injury. We previously described the dihydroquinoline–...

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Detalles Bibliográficos
Autores principales: D’Erasmo, Michael P., Akins, Nicholas S., Ma, Peipei, Jing, Yao, Swanger, Sharon A., Sharma, Savita K., Bartsch, Perry W., Menaldino, David S., Arcoria, Paul J., Bui, Thi-Thien, Pons-Bennaceur, Alexandre, Le, Phuong, Allen, James P., Ullman, Elijah Z., Nocilla, Kelsey A., Zhang, Jing, Perszyk, Riley E., Kim, Sukhan, Acker, Timothy M., Taz, Azmain, Burton, Samantha L., Coe, Kevin, Fritzemeier, Russell G., Burnashev, Nail, Yuan, Hongjie, Liotta, Dennis C., Traynelis, Stephen F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10485906/
https://www.ncbi.nlm.nih.gov/pubmed/37566734
http://dx.doi.org/10.1021/acschemneuro.3c00181

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