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Supraphysiologic doses of 17β-estradiol aggravate depression-like behaviors in ovariectomized mice possibly via regulating microglial responses and brain glycerophospholipid metabolism

BACKGROUND: 17β-Estradiol (E2) is generally considered neuroprotective in humans. However, the current clinical use of estrogen replacement therapy (ERT) is based on the physiological dose of E2 to treat menopausal syndrome and has limited therapeutic efficacy. The efficacy and potential toxicity of...

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Detalles Bibliográficos
Autores principales:	Li, Ming, Zhang, Jing, Chen, Wendi, Liu, Shuang, Liu, Xin, Ning, Yunna, Cao, Yongzhi, Zhao, Yueran
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10485970/ https://www.ncbi.nlm.nih.gov/pubmed/37679787 http://dx.doi.org/10.1186/s12974-023-02889-5

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