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Antileukemic effect of venetoclax and hypomethylating agents via caspase-3/GSDME-mediated pyroptosis

BACKGROUND: The identifying of B-cell lymphoma 2 (Bcl-2) as a therapeutic target has led to a paradigm shift in acute myeloid leukemia (AML) treatment. Pyroptosis is a novel antitumor therapeutic mechanism due to its cytotoxic and immunogenic effects. The combination of venetoclax and hypomethylatin...

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Detalles Bibliográficos
Autores principales:	Ye, Fanghua, Zhang, Wen, Fan, Chenying, Dong, Jiajia, Peng, Min, Deng, Wenjun, Zhang, Hui, Yang, Liangchun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10486003/ https://www.ncbi.nlm.nih.gov/pubmed/37679782 http://dx.doi.org/10.1186/s12967-023-04481-0

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