Pyrroloquinoline quinone drives ATP synthesis in vitro and in vivo and provides retinal ganglion cell neuroprotection

Retinal ganglion cells are highly metabolically active requiring strictly regulated metabolism and functional mitochondria to keep ATP levels in physiological range. Imbalances in metabolism and mitochondrial mechanisms can be sufficient to induce a depletion of ATP, thus altering retinal ganglion c...

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Detalles Bibliográficos
Autores principales: Canovai, Alessio, Tribble, James R., Jöe, Melissa, Westerlund, Daniela Y., Amato, Rosario, Trounce, Ian A., Dal Monte, Massimo, Williams, Pete A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10486004/
https://www.ncbi.nlm.nih.gov/pubmed/37684640
http://dx.doi.org/10.1186/s40478-023-01642-6

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