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The functions and clinical application potential of exosomes derived from mesenchymal stem cells on wound repair: a review of recent research advances

Wound repair is a complex problem for both clinical practitioners and scientific investigators. Conventional approaches to wound repair have been associated with several limitations, including prolonged treatment duration, high treatment expenses, and significant economic and psychological strain on...

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Autores principales: Qin, Xinchi, He, Jia, Wang, Xiaoxiang, Wang, Jingru, Yang, Ronghua, Chen, Xiaodong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10486026/
https://www.ncbi.nlm.nih.gov/pubmed/37691943
http://dx.doi.org/10.3389/fimmu.2023.1256687
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author Qin, Xinchi
He, Jia
Wang, Xiaoxiang
Wang, Jingru
Yang, Ronghua
Chen, Xiaodong
author_facet Qin, Xinchi
He, Jia
Wang, Xiaoxiang
Wang, Jingru
Yang, Ronghua
Chen, Xiaodong
author_sort Qin, Xinchi
collection PubMed
description Wound repair is a complex problem for both clinical practitioners and scientific investigators. Conventional approaches to wound repair have been associated with several limitations, including prolonged treatment duration, high treatment expenses, and significant economic and psychological strain on patients. Consequently, there is a pressing demand for more efficacious and secure treatment modalities to enhance the existing treatment landscapes. In the field of wound repair, cell-free therapy, particularly the use of mesenchymal stem cell-derived exosomes (MSC-Exos), has made notable advancements in recent years. Exosomes, which are small lipid bilayer vesicles discharged by MSCs, harbor bioactive constituents such as proteins, lipids, microRNA (miRNA), and messenger RNA (mRNA). These constituents facilitate material transfer and information exchange between the cells, thereby regulating their biological functions. This article presents a comprehensive survey of the function and mechanisms of MSC-Exos in the context of wound healing, emphasizing their beneficial impact on each phase of the process, including the regulation of the immune response, inhibition of inflammation, promotion of angiogenesis, advancement of cell proliferation and migration, and reduction of scar formation.
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spelling pubmed-104860262023-09-09 The functions and clinical application potential of exosomes derived from mesenchymal stem cells on wound repair: a review of recent research advances Qin, Xinchi He, Jia Wang, Xiaoxiang Wang, Jingru Yang, Ronghua Chen, Xiaodong Front Immunol Immunology Wound repair is a complex problem for both clinical practitioners and scientific investigators. Conventional approaches to wound repair have been associated with several limitations, including prolonged treatment duration, high treatment expenses, and significant economic and psychological strain on patients. Consequently, there is a pressing demand for more efficacious and secure treatment modalities to enhance the existing treatment landscapes. In the field of wound repair, cell-free therapy, particularly the use of mesenchymal stem cell-derived exosomes (MSC-Exos), has made notable advancements in recent years. Exosomes, which are small lipid bilayer vesicles discharged by MSCs, harbor bioactive constituents such as proteins, lipids, microRNA (miRNA), and messenger RNA (mRNA). These constituents facilitate material transfer and information exchange between the cells, thereby regulating their biological functions. This article presents a comprehensive survey of the function and mechanisms of MSC-Exos in the context of wound healing, emphasizing their beneficial impact on each phase of the process, including the regulation of the immune response, inhibition of inflammation, promotion of angiogenesis, advancement of cell proliferation and migration, and reduction of scar formation. Frontiers Media S.A. 2023-08-25 /pmc/articles/PMC10486026/ /pubmed/37691943 http://dx.doi.org/10.3389/fimmu.2023.1256687 Text en Copyright © 2023 Qin, He, Wang, Wang, Yang and Chen https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Qin, Xinchi
He, Jia
Wang, Xiaoxiang
Wang, Jingru
Yang, Ronghua
Chen, Xiaodong
The functions and clinical application potential of exosomes derived from mesenchymal stem cells on wound repair: a review of recent research advances
title The functions and clinical application potential of exosomes derived from mesenchymal stem cells on wound repair: a review of recent research advances
title_full The functions and clinical application potential of exosomes derived from mesenchymal stem cells on wound repair: a review of recent research advances
title_fullStr The functions and clinical application potential of exosomes derived from mesenchymal stem cells on wound repair: a review of recent research advances
title_full_unstemmed The functions and clinical application potential of exosomes derived from mesenchymal stem cells on wound repair: a review of recent research advances
title_short The functions and clinical application potential of exosomes derived from mesenchymal stem cells on wound repair: a review of recent research advances
title_sort functions and clinical application potential of exosomes derived from mesenchymal stem cells on wound repair: a review of recent research advances
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10486026/
https://www.ncbi.nlm.nih.gov/pubmed/37691943
http://dx.doi.org/10.3389/fimmu.2023.1256687
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